TY - JOUR
T1 - White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID)
T2 - Knowledge gaps and opportunities
AU - Alber, Jessica
AU - Alladi, Suvarna
AU - Bae, Hee Joon
AU - Barton, David A.
AU - Beckett, Laurel A.
AU - Bell, Joanne M.
AU - Berman, Sara E.
AU - Biessels, Geert Jan
AU - Black, Sandra E.
AU - Bos, Isabelle
AU - Bowman, Gene L.
AU - Brai, Emanuele
AU - Brickman, Adam M.
AU - Callahan, Brandy L.
AU - Corriveau, Roderick A.
AU - Fossati, Silvia
AU - Gottesman, Rebecca F.
AU - Gustafson, Deborah R.
AU - Hachinski, Vladimir
AU - Hayden, Kathleen M.
AU - Helman, Alex M.
AU - Hughes, Timothy M.
AU - Isaacs, Jeremy D.
AU - Jefferson, Angela L.
AU - Johnson, Sterling C.
AU - Kapasi, Alifiya
AU - Kern, Silke
AU - Kwon, Jay C.
AU - Kukolja, Juraj
AU - Lee, Athene
AU - Lockhart, Samuel N.
AU - Murray, Anne
AU - Osborn, Katie E.
AU - Power, Melinda C.
AU - Price, Brittani R.
AU - Rhodius-Meester, Hanneke F.M.
AU - Rondeau, Jacqueline A.
AU - Rosen, Allyson C.
AU - Rosene, Douglas L.
AU - Schneider, Julie A.
AU - Scholtzova, Henrieta
AU - Shaaban, C. Elizabeth
AU - Silva, Narlon C.B.S.
AU - Snyder, Heather M.
AU - Swardfager, Walter
AU - Troen, Aron M.
AU - van Veluw, Susanne J.
AU - Vemuri, Prashanthi
AU - Wallin, Anders
AU - Wellington, Cheryl
AU - Wilcock, Donna M.
AU - Xie, Sharon Xiangwen
AU - Hainsworth, Atticus H.
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019
Y1 - 2019
N2 - White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.
AB - White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.
KW - Leukoaraiosis
KW - Small vessel disease
KW - Vascular cognitive impairment
KW - Vascular dementia
KW - White matter lesions
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U2 - 10.1016/j.trci.2019.02.001
DO - 10.1016/j.trci.2019.02.001
M3 - Short survey
AN - SCOPUS:85063999193
VL - 5
SP - 107
EP - 117
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
ER -