White Matter Hyperintensity Associations with Cerebral Blood Flow in Elderly Subjects Stratified by Cerebrovascular Risk

Ahmed A. Bahrani, David K. Powell, Guoquiang Yu, Eleanor S. Johnson, Gregory A. Jicha, Charles D. Smith

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objective This study aims to add clarity to the relationship between deep and periventricular brain white matter hyperintensities (WMHs), cerebral blood flow (CBF), and cerebrovascular risk in older persons. Methods Deep white matter hyperintensity (dWMH) and periventricular white matter hyperintensity (pWMH) and regional gray matter (GM) and white matter (WM) blood flow from arterial spin labeling were quantified from magnetic resonance imaging scans of 26 cognitively normal elderly subjects stratified by cerebrovascular disease (CVD) risk. Fluid-attenuated inversion recovery images were acquired using a high-resolution 3-dimensional (3-D) sequence that reduced partial volume effects seen with slice-based techniques. Results dWMHs but not pWMHs were increased in patients at high risk of CVD; pWMHs but not dWMHs were associated with decreased regional cortical (GM) blood flow. We also found that blood flow in WM is decreased in regions of both pWMH and dWMH, with a greater degree of decrease in pWMH areas. Conclusions WMHs are usefully divided into dWMH and pWMH regions because they demonstrate differential effects. 3-D regional WMH volume is a potentially valuable marker for CVD based on associations with cortical CBF and WM CBF.

Original languageEnglish
Pages (from-to)779-786
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number4
StatePublished - Apr 1 2017

Bibliographical note

Funding Information:
Grant support: This study was supported by a pilot award (G.Y.) from the National Institutes of Health (NIH) P30 #AG028383 and a grant-in-aid (G.Y.) from the American Heart Association (AHA) #16GRNT30820006.

Publisher Copyright:
© 2017 The Authors


  • White matter hyperintensities
  • arterial spin-labeling image
  • cerebral blood flow
  • fluid-attenuated inversion recovery
  • segmentation
  • small-vessel disease
  • vascular risk

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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