White matter integrity analysis along cingulum paths in mild cognitive impairment - A geodesic distance approach

Xuwei Liang, Jun Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

We present a new analysis scheme to measure regional micro structural white matter (WM) changes along the major cingulum fiber bundles which may not be effectively performed by existing methods due to its curved geospatial feature. The primary advantages of the technique lie in the diffusion tensor imaging tractography and geodesic distance mapping. The volumetric major cingulum is represented by a reconstructed fiber bundle. Quantitative analysis of regional micro structural WM alterations is based on the geodesic distance mapping, which allows cross-subject evaluation of diffusion properties by establishing correspondences through reparameterizing the space of reconstructed fiber bundle as a function of geodesic distance. Evaluation of the technique explores regional fractional anisotropy degradations along the left cingulum path in amnestic mild cognitive impairment subjects. Our experimental results indicate that this approach is effective and may provide a more sensitive alternative to examining the WM integrity of brain neuronal connectivity.

Original languageEnglish
Title of host publication2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008
Pages510-513
Number of pages4
DOIs
StatePublished - 2008
Event2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008 - Shanghai, China
Duration: May 16 2008May 18 2008

Publication series

Name2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008

Conference

Conference2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008
Country/TerritoryChina
CityShanghai
Period5/16/085/18/08

Keywords

  • Cingulum
  • Diffusion tensor imaging
  • Geodesic distance
  • Mild cognitive impairment
  • Tractography

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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