TY - GEN
T1 - White matter integrity analysis along cingulum paths in mild cognitive impairment - A geodesic distance approach
AU - Liang, Xuwei
AU - Zhang, Jun
PY - 2008
Y1 - 2008
N2 - We present a new analysis scheme to measure regional micro structural white matter (WM) changes along the major cingulum fiber bundles which may not be effectively performed by existing methods due to its curved geospatial feature. The primary advantages of the technique lie in the diffusion tensor imaging tractography and geodesic distance mapping. The volumetric major cingulum is represented by a reconstructed fiber bundle. Quantitative analysis of regional micro structural WM alterations is based on the geodesic distance mapping, which allows cross-subject evaluation of diffusion properties by establishing correspondences through reparameterizing the space of reconstructed fiber bundle as a function of geodesic distance. Evaluation of the technique explores regional fractional anisotropy degradations along the left cingulum path in amnestic mild cognitive impairment subjects. Our experimental results indicate that this approach is effective and may provide a more sensitive alternative to examining the WM integrity of brain neuronal connectivity.
AB - We present a new analysis scheme to measure regional micro structural white matter (WM) changes along the major cingulum fiber bundles which may not be effectively performed by existing methods due to its curved geospatial feature. The primary advantages of the technique lie in the diffusion tensor imaging tractography and geodesic distance mapping. The volumetric major cingulum is represented by a reconstructed fiber bundle. Quantitative analysis of regional micro structural WM alterations is based on the geodesic distance mapping, which allows cross-subject evaluation of diffusion properties by establishing correspondences through reparameterizing the space of reconstructed fiber bundle as a function of geodesic distance. Evaluation of the technique explores regional fractional anisotropy degradations along the left cingulum path in amnestic mild cognitive impairment subjects. Our experimental results indicate that this approach is effective and may provide a more sensitive alternative to examining the WM integrity of brain neuronal connectivity.
KW - Cingulum
KW - Diffusion tensor imaging
KW - Geodesic distance
KW - Mild cognitive impairment
KW - Tractography
UR - http://www.scopus.com/inward/record.url?scp=50949130145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50949130145&partnerID=8YFLogxK
U2 - 10.1109/ICBBE.2008.124
DO - 10.1109/ICBBE.2008.124
M3 - Conference contribution
AN - SCOPUS:50949130145
SN - 9781424417483
T3 - 2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008
SP - 510
EP - 513
BT - 2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008
T2 - 2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008
Y2 - 16 May 2008 through 18 May 2008
ER -