Wild type but not mutant APP is involved in protective adaptive responses against oxidants

Giovanna Cenini, Giuseppina MacCarinelli, Cristina Lanni, Sara Anna Bonini, Giulia Ferrari-Toninelli, Stefano Govoni, Marco Racchi, David Allan Butterfield, Maurizio Memo, Daniela Uberti

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This study points out different behaviour between HEK cells overexpressing wild-type or mutant APP when exposed to oxidative insult. Although apparently both APPwt and APPmut overexpression conferred resistance to oxidative insult, some differences in terms of degree of protection was observed in the two clones. We found that the two clones differed, especially, in terms of redox profile. HEK-APPmut cells were characterized by higher levels of oxidative markers in comparison with HEK-APPwt. In addition, SOD activity appeared more efficient in HEK-APPwt than in HEK-APPmut, thus justifying the differences in terms of cell survival in the two clones. We suggest that, according to "hormesis theory", in HEK-APPwt cells low amount of oxidative stress can exert a beneficial effect that at a higher intensity results harmful. In contrast, HEK-APPmut cells lost this stress resistance probably because the degree of oxidative stress is too high and the antioxidant enzymes are themselves compromised.

Original languageEnglish
Pages (from-to)271-283
Number of pages13
JournalAmino Acids
Issue number1
StatePublished - Jun 2010

Bibliographical note

Funding Information:
This research was supported in part by NIH grants (AG-10896; AG -05119) to D.A.B. and by PRIN 2007 grant from the Italian Ministry of Education, University and Research to S.G. and M.M.


  • APP, p53
  • Adaptive response
  • Cell vulnerability
  • Oxidative stress
  • SOD

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Clinical Biochemistry


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