World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid

J. Taylor, R. McMillan, M. Shephard, J. Setterfield, R. Ahmed, M. Carrozzo, S. Grando, M. Mignogna, M. Kuten-Shorrer, T. Musbah, A. Elia, R. McGowan, A. R. Kerr, M. S. Greenberg, T. Hodgson, D. Sirois

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

Original languageEnglish
Pages (from-to)161-171.e20
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume120
Issue number2
DOIs
StatePublished - 2015

Bibliographical note

Funding Information:
The following organizations, individuals and companies provided unrestricted financial support for WWOM VI and this study: American Academy of Oral Medicine, European Association of Oral Medicine, anonymous gifts from patients of Dr. David Sirois, New York University College of Dentistry, Biocosmetics, Elsevier, Johnson and Johnson, The Oral Cancer Foundation, and Unilever.

Funding Information:
The authors would like to gratefully acknowledge the following organizations, individuals and companies that provided unrestricted financial support of WWOM VI: American Academy of Oral Medicine, European Association of Oral Medicine, anonymous gifts from patients of Dr. David Sirois, New York University College of Dentistry, Biocosmetics, Elsevier, Johnson and Johnson, The Oral Cancer Foundation, and Unilever.

Publisher Copyright:
© 2015 Elsevier Inc.

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

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