World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid

J. Taylor, R. McMillan, M. Shephard, J. Setterfield, R. Ahmed, M. Carrozzo, S. Grando, M. Mignogna, M. Kuten-Shorrer, T. Musbah, A. Elia, R. McGowan, A. R. Kerr, M. S. Greenberg, T. Hodgson, D. Sirois

    Research output: Contribution to journalArticlepeer-review

    54 Scopus citations

    Abstract

    Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

    Original languageEnglish
    Pages (from-to)161-171.e20
    JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
    Volume120
    Issue number2
    DOIs
    StatePublished - 2015

    Bibliographical note

    Publisher Copyright:
    © 2015 Elsevier Inc.

    ASJC Scopus subject areas

    • Surgery
    • Oral Surgery
    • Pathology and Forensic Medicine
    • Dentistry (miscellaneous)
    • Radiology Nuclear Medicine and imaging

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