World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid

J. Taylor; R. McMillan; M. Shephard; J. Setterfield; R. Ahmed; M. Carrozzo; S. Grando; M. Mignogna; M. Kuten-Shorrer; T. Musbah; A. Elia; R. McGowan; A. R. Kerr; M. S. Greenberg; T. Hodgson; D. Sirois

doi:10.1016/j.oooo.2015.01.024

World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid

J. Taylor, R. McMillan, M. Shephard, J. Setterfield, R. Ahmed, M. Carrozzo, S. Grando, M. Mignogna, M. Kuten-Shorrer, T. Musbah, A. Elia, R. McGowan, A. R. Kerr, M. S. Greenberg, T. Hodgson, D. Sirois

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

Original language	English
Pages (from-to)	161-171.e20
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/j.oooo.2015.01.024
State	Published - 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Funding

The following organizations, individuals and companies provided unrestricted financial support for WWOM VI and this study: American Academy of Oral Medicine, European Association of Oral Medicine, anonymous gifts from patients of Dr. David Sirois, New York University College of Dentistry, Biocosmetics, Elsevier, Johnson and Johnson, The Oral Cancer Foundation, and Unilever. The authors would like to gratefully acknowledge the following organizations, individuals and companies that provided unrestricted financial support of WWOM VI: American Academy of Oral Medicine, European Association of Oral Medicine, anonymous gifts from patients of Dr. David Sirois, New York University College of Dentistry, Biocosmetics, Elsevier, Johnson and Johnson, The Oral Cancer Foundation, and Unilever.

Funders	Funder number
New York University College of Dentistry, Biocosmetics, Elsevier, Johnson and Johnson
Oral Cancer Foundation
Unilever

ASJC Scopus subject areas

Surgery
Oral Surgery
Pathology and Forensic Medicine
Dentistry (miscellaneous)
Radiology Nuclear Medicine and imaging

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10.1016/j.oooo.2015.01.024

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Taylor, J., McMillan, R., Shephard, M., Setterfield, J., Ahmed, R., Carrozzo, M., Grando, S., Mignogna, M., Kuten-Shorrer, M., Musbah, T., Elia, A., McGowan, R., Kerr, A. R., Greenberg, M. S., Hodgson, T., & Sirois, D. (2015). World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 120(2), 161-171.e20. https://doi.org/10.1016/j.oooo.2015.01.024

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abstract = "Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.",

author = "J. Taylor and R. McMillan and M. Shephard and J. Setterfield and R. Ahmed and M. Carrozzo and S. Grando and M. Mignogna and M. Kuten-Shorrer and T. Musbah and A. Elia and R. McGowan and Kerr, \{A. R.\} and Greenberg, \{M. S.\} and T. Hodgson and D. Sirois",

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Taylor, J, McMillan, R, Shephard, M, Setterfield, J, Ahmed, R, Carrozzo, M, Grando, S, Mignogna, M, Kuten-Shorrer, M, Musbah, T, Elia, A, McGowan, R, Kerr, AR, Greenberg, MS, Hodgson, T & Sirois, D 2015, 'World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 120, no. 2, pp. 161-171.e20. https://doi.org/10.1016/j.oooo.2015.01.024

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T1 - World Workshop on Oral Medicine VI

T2 - A systematic review of the treatment of mucous membrane pemphigoid

AU - Taylor, J.

AU - McMillan, R.

AU - Shephard, M.

AU - Setterfield, J.

AU - Ahmed, R.

AU - Carrozzo, M.

AU - Grando, S.

AU - Mignogna, M.

AU - Kuten-Shorrer, M.

AU - Musbah, T.

AU - Elia, A.

AU - McGowan, R.

AU - Kerr, A. R.

AU - Greenberg, M. S.

AU - Hodgson, T.

AU - Sirois, D.

PY - 2015

Y1 - 2015

N2 - Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

AB - Objective To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

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World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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