TY - JOUR
T1 - WWOM VII
T2 - Effectiveness of topical interventions in the management of burning mouth syndrome: A systematic review
AU - Goncalves, Sandra
AU - Carey, Barbara
AU - Farag, Arwa M.
AU - Kuten-Shorrer, Michal
AU - Natto, Zuhair S.
AU - Ariyawardana, Anura
AU - Mejia, Lina M.
AU - Chmieliauskaite, Milda
AU - Miller, Craig S.
AU - Ingram, Mark
AU - Nasri-Heir, Cibele
AU - Sardella, Andrea
AU - Carlson, Charles R.
AU - Klasser, Gary D.
AU - O'Neill, Francis
AU - Albuquerque, Rui
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2023/11
Y1 - 2023/11
N2 - Objectives: To assess the effectiveness of topical interventions in the management of burning mouth syndrome (BMS), based on the core outcome domains recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT). Methods: A systematic literature review of RCTs on topical interventions for the management of BMS, published in PubMed, Web of Science, PsycInfo, Cochrane Database/Central, and Google Scholar through May 2021 was performed. Results: Eight RCTs (n = 358 study participants) were included in this study. Due to underreporting of IMMPACT domains, publication bias, high degree of heterogeneity between studies, meta-analysis was not undertaken. Based on changes in visual analogue pain scores (ΔVAS), the most reported outcome, the effectiveness of the topical interventions was demonstrated; however, it is low level of evidence. Conclusions: High levels of variability (interventions, outcomes, outcome measurement tools, and intervention effects evaluated), heterogeneity, publication bias, and underreporting of IMMPACT domains were observed across the RCTs. This systematic review highlights the need for application of standardized outcome measures to future RCTs. At the present time, there is lack of moderate-strong evidence on short- and long-term outcomes to support or refute the use of any particular topical intervention in managing BMS. Future RCTs with standardized outcome measures are needed.
AB - Objectives: To assess the effectiveness of topical interventions in the management of burning mouth syndrome (BMS), based on the core outcome domains recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT). Methods: A systematic literature review of RCTs on topical interventions for the management of BMS, published in PubMed, Web of Science, PsycInfo, Cochrane Database/Central, and Google Scholar through May 2021 was performed. Results: Eight RCTs (n = 358 study participants) were included in this study. Due to underreporting of IMMPACT domains, publication bias, high degree of heterogeneity between studies, meta-analysis was not undertaken. Based on changes in visual analogue pain scores (ΔVAS), the most reported outcome, the effectiveness of the topical interventions was demonstrated; however, it is low level of evidence. Conclusions: High levels of variability (interventions, outcomes, outcome measurement tools, and intervention effects evaluated), heterogeneity, publication bias, and underreporting of IMMPACT domains were observed across the RCTs. This systematic review highlights the need for application of standardized outcome measures to future RCTs. At the present time, there is lack of moderate-strong evidence on short- and long-term outcomes to support or refute the use of any particular topical intervention in managing BMS. Future RCTs with standardized outcome measures are needed.
KW - IMMPACT
KW - burning mouth syndrome
KW - clinical trials
KW - outcomes
KW - systemic interventions
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U2 - 10.1111/odi.14297
DO - 10.1111/odi.14297
M3 - Review article
C2 - 35781729
AN - SCOPUS:85136288025
SN - 1354-523X
VL - 29
SP - 3016
EP - 3033
JO - Oral Diseases
JF - Oral Diseases
IS - 8
ER -