Xenogenous collagen matrix and/or enamel matrix derivative for treatment of localized gingival recessions: A randomized clinical trial. Part I: Clinical outcomes

João Paulo Menck Sangiorgio, Felipe Lucas Da Silva Neves, Manuela Rocha Dos Santos, Isabela Lima França-Grohmann, Renato Corrêa Viana Casarin, Márcio Zaffalon Casati, Mauro Pedrine Santamaria, Enilson Antonio Sallum

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Background: Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double-masked, dual-center, randomized clinical trial is to evaluate clinical outcomes after treatment of localized gingival recession (GR) by a coronally advanced flap (CAF) combined with CM and/or EMD. Methods: Sixty-eight patients presenting one Miller Class I or II GRs were randomly assigned to receive either CAF (n = 17); CAF + CM (n = 17); CAF + EMD (n = 17), or CAF + CM + EMD (n = 17). Recession height, probing depth, clinical attachment level, and keratinized tissue width and thickness were measured at baseline and 90 days and 6 months after surgery. Results: The obtained root coverage was 68.04% ± 24.11% for CAF; 87.20% ± 15.01% for CAF + CM; 88.77% ± 20.66% for CAF + EMD; and 91.59% ± 11.08% for CAF + CM + EMD after 6 months. Groups that received biomaterials showed greater values (P <0.05). Complete root coverage (CRC) for CAF + EMD was 70.59%, significantly superior to CAF alone (23.53%); CAF + CM (52.94%), and CAF + CM + EMD (51.47%) (P <0.05). Keratinized tissue thickness gain was significant only in CM-treated groups (P <0.05). Conclusions: The three approaches are superior to CAF alone for root coverage. EMD provides highest levels of CRC; however, the addition of CM increases gingival thickness. The combination approach does not seem justified.

Original languageEnglish
Pages (from-to)1309-1318
Number of pages10
JournalJournal of Periodontology
Issue number12
StatePublished - Dec 2017

Bibliographical note

Funding Information:
The authors appreciate the financial support provided by the Research Funding Agency from São Paulo State (FAPESP), São Paulo, SP, Brazil (Grant 2013/ 19473-6 to Dr. Enilson Sallum). The authors would like to recognize Thiago Ozi Bueno and Tiago Tarbes Vianna, (PhD students, Piracicaba Dental School, State University of Campinas, Campinas, Brazil) who served as examiners for the esthetic evaluation. The authors report no conflicts of interest related to this study.


  • Collagen
  • Enamel matrix proteins
  • General surgery
  • Gingival recession
  • Surgery, plastic
  • Tooth root

ASJC Scopus subject areas

  • Periodontics


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