Yeast sphingolipid metabolism: Clues and connections

Kellie J. Sims, Stefka D. Spassieva, Eberhard O. Voit, Lina M. Obeid

Research output: Contribution to journalShort surveypeer-review

56 Scopus citations


This review of sphingolipid metabolism in the budding yeast Saccharomyces cerevisiae contains information on the enzymes and the genes that encode them, as well as connections to other metabolic pathways. Particular attention is given to yeast homologs, domains, and motifs in the sequence, cellular localization of enzymes, and possible protein-protein interactions. Also included are genetic interactions of special interest that provide clues to the cellular biological roles of particular sphingolipid metabolic pathways and specific sphingolipids.

Original languageEnglish
Pages (from-to)45-61
Number of pages17
JournalBiochemistry and Cell Biology
Issue number1
StatePublished - Feb 2004


  • Aging
  • Protein-protein interactions
  • Sphingolipid metabolism
  • Stress response
  • Subcellular localization
  • Yeast

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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