Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats

Linda P. Dwoskin, Bethany S. Neal, Sheldon B. Sparber

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The involvement of α2-noradrenergic receptors in the expression of opiate withdrawal was studied using an operant behavioral model of acute morphine dependence. Clonidine, an α2-agonist, attenuated and yohimbine, an α2-antagonist, exacerbated the naloxone-induced suppression of fixed ratio 15 responding in rats pretreated several hours earlier with a single, moderate dose of morphine. These data indicate that the α2-agonist action of clonidine is responsible for its amelioration of withdrawal symptoms. It also validates the acute dependence model for studying the pharmacology of opiates and associated adaptive processes.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - Jun 3 1983

Bibliographical note

Funding Information:
* Supported in part by USPHS Grants DA00532 and GM07397. ** To whom all correspondence should be addressed: Depart-ment of Pharmacology, Medical School, University of Min-nesota, 3-260 Millard Hall, 435 Delaware Street S.E., Mpls., MN 55455, U.S.A.


  • Clonidine
  • Dependence
  • Morphine
  • Operant behavior
  • Yohimbine

ASJC Scopus subject areas

  • Pharmacology


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