Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats

Linda P. Dwoskin; Bethany S. Neal; Sheldon B. Sparber

doi:10.1016/0014-2999(83)90248-0

Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats

Linda P. Dwoskin, Bethany S. Neal, Sheldon B. Sparber

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The involvement of α₂-noradrenergic receptors in the expression of opiate withdrawal was studied using an operant behavioral model of acute morphine dependence. Clonidine, an α₂-agonist, attenuated and yohimbine, an α₂-antagonist, exacerbated the naloxone-induced suppression of fixed ratio 15 responding in rats pretreated several hours earlier with a single, moderate dose of morphine. These data indicate that the α₂-agonist action of clonidine is responsible for its amelioration of withdrawal symptoms. It also validates the acute dependence model for studying the pharmacology of opiates and associated adaptive processes.

Original language	English
Pages (from-to)	269-273
Number of pages	5
Journal	European Journal of Pharmacology
Volume	90
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(83)90248-0
State	Published - Jun 3 1983

Bibliographical note

Funding Information:
* Supported in part by USPHS Grants DA00532 and GM07397. ** To whom all correspondence should be addressed: Depart-ment of Pharmacology, Medical School, University of Min-nesota, 3-260 Millard Hall, 435 Delaware Street S.E., Mpls., MN 55455, U.S.A.

Keywords

Clonidine
Dependence
Morphine
Operant behavior
Yohimbine

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(83)90248-0

Cite this

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title = "Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats",

abstract = "The involvement of α2-noradrenergic receptors in the expression of opiate withdrawal was studied using an operant behavioral model of acute morphine dependence. Clonidine, an α2-agonist, attenuated and yohimbine, an α2-antagonist, exacerbated the naloxone-induced suppression of fixed ratio 15 responding in rats pretreated several hours earlier with a single, moderate dose of morphine. These data indicate that the α2-agonist action of clonidine is responsible for its amelioration of withdrawal symptoms. It also validates the acute dependence model for studying the pharmacology of opiates and associated adaptive processes.",

keywords = "Clonidine, Dependence, Morphine, Operant behavior, Yohimbine",

author = "Dwoskin, {Linda P.} and Neal, {Bethany S.} and Sparber, {Sheldon B.}",

note = "Funding Information: * Supported in part by USPHS Grants DA00532 and GM07397. ** To whom all correspondence should be addressed: Depart-ment of Pharmacology, Medical School, University of Min-nesota, 3-260 Millard Hall, 435 Delaware Street S.E., Mpls., MN 55455, U.S.A.",

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AU - Dwoskin, Linda P.

AU - Neal, Bethany S.

AU - Sparber, Sheldon B.

N1 - Funding Information: * Supported in part by USPHS Grants DA00532 and GM07397. ** To whom all correspondence should be addressed: Depart-ment of Pharmacology, Medical School, University of Min-nesota, 3-260 Millard Hall, 435 Delaware Street S.E., Mpls., MN 55455, U.S.A.

PY - 1983/6/3

Y1 - 1983/6/3

N2 - The involvement of α2-noradrenergic receptors in the expression of opiate withdrawal was studied using an operant behavioral model of acute morphine dependence. Clonidine, an α2-agonist, attenuated and yohimbine, an α2-antagonist, exacerbated the naloxone-induced suppression of fixed ratio 15 responding in rats pretreated several hours earlier with a single, moderate dose of morphine. These data indicate that the α2-agonist action of clonidine is responsible for its amelioration of withdrawal symptoms. It also validates the acute dependence model for studying the pharmacology of opiates and associated adaptive processes.

AB - The involvement of α2-noradrenergic receptors in the expression of opiate withdrawal was studied using an operant behavioral model of acute morphine dependence. Clonidine, an α2-agonist, attenuated and yohimbine, an α2-antagonist, exacerbated the naloxone-induced suppression of fixed ratio 15 responding in rats pretreated several hours earlier with a single, moderate dose of morphine. These data indicate that the α2-agonist action of clonidine is responsible for its amelioration of withdrawal symptoms. It also validates the acute dependence model for studying the pharmacology of opiates and associated adaptive processes.

KW - Clonidine

KW - Dependence

KW - Morphine

KW - Operant behavior

KW - Yohimbine

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JO - European Journal of Pharmacology

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ER -

Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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