Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

Martha L. Peterson; Chunhong Ma; Brett T. Spear

doi:10.1016/j.semcancer.2011.01.001

Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

Martha L. Peterson, Chunhong Ma, Brett T. Spear

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.

Original language	English
Pages (from-to)	21-27
Number of pages	7
Journal	Seminars in Cancer Biology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.semcancer.2011.01.001
State	Published - Feb 2011

Bibliographical note

Funding Information:
Some of the studies described here were supported by Public Health Service Grants DK074816 (B.T.S.) and DK059866 (B.T.S. and M.L.P.)

Keywords

Alpha-fetoprotein
Development
Hepatocellular carcinoma
Liver
Mouse
Transcription

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2011.01.001

Cite this

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title = "Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer",

abstract = "The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.",

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AU - Ma, Chunhong

AU - Spear, Brett T.

N1 - Funding Information: Some of the studies described here were supported by Public Health Service Grants DK074816 (B.T.S.) and DK059866 (B.T.S. and M.L.P.)

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AB - The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.

KW - Alpha-fetoprotein

KW - Development

KW - Hepatocellular carcinoma

KW - Liver

KW - Mouse

KW - Transcription

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Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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