Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

Martha L. Peterson; Chunhong Ma; Brett T. Spear

doi:10.1016/j.semcancer.2011.01.001

Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.

Original language	English
Pages (from-to)	21-27
Number of pages	7
Journal	Seminars in Cancer Biology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.semcancer.2011.01.001
State	Published - Feb 2011

Bibliographical note

Funding Information:
Some of the studies described here were supported by Public Health Service Grants DK074816 (B.T.S.) and DK059866 (B.T.S. and M.L.P.)

Funding

Some of the studies described here were supported by Public Health Service Grants DK074816 (B.T.S.) and DK059866 (B.T.S. and M.L.P.)

Funders	Funder number
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK059866
U.S. Public Health Service	DK059866, DK074816

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alpha-fetoprotein
Development
Hepatocellular carcinoma
Liver
Mouse
Transcription

ASJC Scopus subject areas

Cancer Research

Access to Document

10.1016/j.semcancer.2011.01.001

Cite this

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title = "Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer",

abstract = "The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.",

keywords = "Alpha-fetoprotein, Development, Hepatocellular carcinoma, Liver, Mouse, Transcription",

author = "Peterson, \{Martha L.\} and Chunhong Ma and Spear, \{Brett T.\}",

note = "Funding Information: Some of the studies described here were supported by Public Health Service Grants DK074816 (B.T.S.) and DK059866 (B.T.S. and M.L.P.)",

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doi = "10.1016/j.semcancer.2011.01.001",

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T2 - Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

AU - Peterson, Martha L.

AU - Ma, Chunhong

AU - Spear, Brett T.

N1 - Funding Information: Some of the studies described here were supported by Public Health Service Grants DK074816 (B.T.S.) and DK059866 (B.T.S. and M.L.P.)

PY - 2011/2

Y1 - 2011/2

N2 - The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.

AB - The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.

KW - Alpha-fetoprotein

KW - Development

KW - Hepatocellular carcinoma

KW - Liver

KW - Mouse

KW - Transcription

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UR - https://www.scopus.com/pages/publications/79952037928#tab=citedBy

U2 - 10.1016/j.semcancer.2011.01.001

DO - 10.1016/j.semcancer.2011.01.001

M3 - Review article

C2 - 21216289

AN - SCOPUS:79952037928

SN - 1044-579X

VL - 21

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EP - 27

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

IS - 1

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Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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