Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

Petraleigh Pantoja; Erick X. Pérez-Guzmán; Idia V. Rodríguez; Laura J. White; Olga González; Crisanta Serrano; Luis Giavedoni; Vida Hodara; Lorna Cruz; Teresa Arana; Melween I. Martínez; Mariah A. Hassert; James D. Brien; Amelia K. Pinto; Aravinda De Silva; Carlos A. Sariol

doi:10.1038/ncomms15674

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

Petraleigh Pantoja, Erick X. Pérez-Guzmán, Idia V. Rodríguez, Laura J. White, Olga González, Crisanta Serrano, Luis Giavedoni, Vida Hodara, Lorna Cruz, Teresa Arana, Melween I. Martínez, Mariah A. Hassert, James D. Brien, Amelia K. Pinto, Aravinda De Silva, Carlos A. Sariol

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to naïve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.

Original language	English
Article number	15674
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms15674
State	Published - Jun 23 2017

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ncomms15674

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Pantoja, P., Pérez-Guzmán, E. X., Rodríguez, I. V., White, L. J., González, O., Serrano, C., Giavedoni, L., Hodara, V., Cruz, L., Arana, T., Martínez, M. I., Hassert, M. A., Brien, J. D., Pinto, A. K., De Silva, A., & Sariol, C. A. (2017). Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus. Nature Communications, 8, Article 15674. https://doi.org/10.1038/ncomms15674

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title = "Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus",

abstract = "Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is na{\"i}ve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to na{\"i}ve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.",

author = "Petraleigh Pantoja and P{\'e}rez-Guzm{\'a}n, {Erick X.} and Rodr{\'i}guez, {Idia V.} and White, {Laura J.} and Olga Gonz{\'a}lez and Crisanta Serrano and Luis Giavedoni and Vida Hodara and Lorna Cruz and Teresa Arana and Mart{\'i}nez, {Melween I.} and Hassert, {Mariah A.} and Brien, {James D.} and Pinto, {Amelia K.} and {De Silva}, Aravinda and Sariol, {Carlos A.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

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doi = "10.1038/ncomms15674",

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Pantoja, P, Pérez-Guzmán, EX, Rodríguez, IV, White, LJ, González, O, Serrano, C, Giavedoni, L, Hodara, V, Cruz, L, Arana, T, Martínez, MI, Hassert, MA, Brien, JD , Pinto, AK, De Silva, A & Sariol, CA 2017, 'Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus', Nature Communications, vol. 8, 15674. https://doi.org/10.1038/ncomms15674

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T1 - Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

AU - Pantoja, Petraleigh

AU - Pérez-Guzmán, Erick X.

AU - Rodríguez, Idia V.

AU - White, Laura J.

AU - González, Olga

AU - Serrano, Crisanta

AU - Giavedoni, Luis

AU - Hodara, Vida

AU - Cruz, Lorna

AU - Arana, Teresa

AU - Martínez, Melween I.

AU - Hassert, Mariah A.

AU - Brien, James D.

AU - Pinto, Amelia K.

AU - De Silva, Aravinda

AU - Sariol, Carlos A.

PY - 2017/6/23

Y1 - 2017/6/23

N2 - Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to naïve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.

AB - Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to naïve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.

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Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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