Zwitterionic amino acid-based Poly(ester urea)s suppress adhesion formation in a rat intra-abdominal cecal abrasion model

Nathan Z. Dreger, Zachary K. Zander, Yen Hao Hsu, D. Luong, P. Chen, N. Le, Trenton Parsell, Clause Søndergaard, Misha L. Dunbar, Nathan J. Koewler, Mark A. Suckow, Matthew L. Becker

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Hernia repair outcomes have improved with more robust material options for surgeons and optimized surgical techniques. However, ventral hernia repairs remain challenging with an inherent risk of post-surgical adhesions in the peritoneal space which can occur regardless of interventional material or its surgical placement. Herein, amino acid-based poly(ester urea)s (PEUs) with varied amount of an allyl ether side chains were modified post polymerization modification with the zwitterionic sulfnate group (3-((3-((3-mercaptopropanoyl)oxy)propyl) dimethylammonio)propane-1-sulfonate) to promote anti-adhesive properties. These alloc-PEUs were processed using roll-to-roll fabrication methods to afford films that were amenable to surface functionalization via a zwitterion-thiol. Functional group availability on the surface was confirmed via fluorescence microscopy, x-ray photoelectron spectroscopy (XPS), and quartz crystal microbalance (QCM) measurements. Zwitterionic treated PEUs exhibited reduced fibrinogen adsorption in vitro when compared to unfunctionalized control polymer. A rat intrabdominal cecal abrasion adhesion model was used to assess the extent and tenacity of adhesion formation in the presence of the PEUs. The 10% alloc-PEU zwitterion functionalized material was found to reduce the extent and tenacity of adhesions when compared to adhesion controls and the unfunctionalized PEU controls.

Original languageEnglish
Article number119399
JournalBiomaterials
Volume221
DOIs
StatePublished - Nov 2019

Bibliographical note

Funding Information:
The authors gratefully acknowledge financial support from Cook Biotech and the W. Gerald Austen Endowed Chair in Polymer Science and Polymer Engineering from the John S. and James L. Knight Foundation. The authors would also like to thank BioStats Inc. for advice on statistical analysis.

Funding Information:
The authors gratefully acknowledge financial support from Cook Biotech and the W. Gerald Austen Endowed Chair in Polymer Science and Polymer Engineering from the John S. and James L. Knight Foundation . The authors would also like to thank BioStats Inc. for advice on statistical analysis.

Publisher Copyright:
© 2019

Keywords

  • Adhesion
  • Hernia
  • Poly(ester urea)s
  • Soft-tissue

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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