Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions

Tao Bai; Sijun Liu; Fang Sun; Andrew Sinclair; Lei Zhang; Qing Shao; Shaoyi Jiang

doi:10.1016/j.biomaterials.2014.01.077

Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions

Tao Bai, Sijun Liu, Fang Sun, Andrew Sinclair, Lei Zhang, Qing Shao, Shaoyi Jiang

Chemical and Materials Engineering

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, "zwitterionic fusion", which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together.

Original language	English
Pages (from-to)	3926-3933
Number of pages	8
Journal	Biomaterials
Volume	35
Issue number	13
DOIs	https://doi.org/10.1016/j.biomaterials.2014.01.077
State	Published - Apr 2014

Bibliographical note

Funding Information:
This work is funded by the Office of Naval Research ( N00014-14-1-0090 ) and the National Science Foundation ( DMR 1307375 ).

Funding

This work is funded by the Office of Naval Research ( N00014-14-1-0090 ) and the National Science Foundation ( DMR 1307375 ).

Funders	Funder number
National Science Foundation (NSF)	1307375, DMR 1307375
Office of Naval Research	N00014-14-1-0090

Keywords

Self-healing materials
Time-independent behavior
Zwitterionic fusion
Zwitterionic materials

ASJC Scopus subject areas

Mechanics of Materials
Ceramics and Composites
Bioengineering
Biophysics
Biomaterials

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10.1016/j.biomaterials.2014.01.077

Cite this

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abstract = "The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, {"}zwitterionic fusion{"}, which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together.",

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author = "Tao Bai and Sijun Liu and Fang Sun and Andrew Sinclair and Lei Zhang and Qing Shao and Shaoyi Jiang",

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AU - Bai, Tao

AU - Liu, Sijun

AU - Sun, Fang

AU - Sinclair, Andrew

AU - Zhang, Lei

AU - Shao, Qing

AU - Jiang, Shaoyi

N1 - Funding Information: This work is funded by the Office of Naval Research ( N00014-14-1-0090 ) and the National Science Foundation ( DMR 1307375 ).

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AB - The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, "zwitterionic fusion", which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together.

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KW - Time-independent behavior

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KW - Zwitterionic materials

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Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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