Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions

Tao Bai, Sijun Liu, Fang Sun, Andrew Sinclair, Lei Zhang, Qing Shao, Shaoyi Jiang

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, "zwitterionic fusion", which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together.

Original languageEnglish
Pages (from-to)3926-3933
Number of pages8
JournalBiomaterials
Volume35
Issue number13
DOIs
StatePublished - Apr 2014

Bibliographical note

Funding Information:
This work is funded by the Office of Naval Research ( N00014-14-1-0090 ) and the National Science Foundation ( DMR 1307375 ).

Keywords

  • Self-healing materials
  • Time-independent behavior
  • Zwitterionic fusion
  • Zwitterionic materials

ASJC Scopus subject areas

  • Mechanics of Materials
  • Ceramics and Composites
  • Bioengineering
  • Biophysics
  • Biomaterials

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