Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions

Tao Bai; Sijun Liu; Fang Sun; Andrew Sinclair; Lei Zhang; Qing Shao; Shaoyi Jiang

doi:10.1016/j.biomaterials.2014.01.077

Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions

Tao Bai, Sijun Liu, Fang Sun, Andrew Sinclair, Lei Zhang, Qing Shao, Shaoyi Jiang

Chemical and Materials Engineering

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, "zwitterionic fusion", which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together.

Original language	English
Pages (from-to)	3926-3933
Number of pages	8
Journal	Biomaterials
Volume	35
Issue number	13
DOIs	https://doi.org/10.1016/j.biomaterials.2014.01.077
State	Published - Apr 2014

Bibliographical note

Funding Information:
This work is funded by the Office of Naval Research ( N00014-14-1-0090 ) and the National Science Foundation ( DMR 1307375 ).

Funding

This work is funded by the Office of Naval Research ( N00014-14-1-0090 ) and the National Science Foundation ( DMR 1307375 ).

Funders	Funder number
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China	1307375, DMR 1307375
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China
Office of Naval Research Naval Academy	N00014-14-1-0090
Office of Naval Research Naval Academy

Keywords

Self-healing materials
Time-independent behavior
Zwitterionic fusion
Zwitterionic materials

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2014.01.077

Cite this

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abstract = "The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, {"}zwitterionic fusion{"}, which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together.",

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author = "Tao Bai and Sijun Liu and Fang Sun and Andrew Sinclair and Lei Zhang and Qing Shao and Shaoyi Jiang",

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AU - Bai, Tao

AU - Liu, Sijun

AU - Sun, Fang

AU - Sinclair, Andrew

AU - Zhang, Lei

AU - Shao, Qing

AU - Jiang, Shaoyi

N1 - Funding Information: This work is funded by the Office of Naval Research ( N00014-14-1-0090 ) and the National Science Foundation ( DMR 1307375 ).

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AB - The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, "zwitterionic fusion", which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together.

KW - Self-healing materials

KW - Time-independent behavior

KW - Zwitterionic fusion

KW - Zwitterionic materials

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Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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