Our research program focuses on understanding the molecular mechanisms through which the fundamental MAPK1/2 pathway is regulated in space and in time.

To that end, we utilize comprehensive and interdisciplinary approaches that incorporate biochemistry, cell biology, state-of-the-art microscopy and vertebrate models. Our current focus is the scaffold protein Shoc2.  We investigate how Shoc2 scaffold controls timing and cellular distribution of MAPK1/2 signaling and how Shoc2 itself is regulated by the ubiquitin machinery.

In our studies, we integrate insights from basic research with the study of human cancers and congenital disorders. We believe that a better understanding of the molecular basis of malignant transformation will lead not only to further advances in biology but also novel and effective therapies.