Proyectos por año
Perfil personal
Research Interests
Dr. Yang's lab studies protein translational control of genes involved in tumor invasion and metastasis. Currently, we focus on investigating how Pdcd4 (Programmed cell death 4), a novel tumor suppressor and a translation inhibitor, impacts on protein translation particularly the genes critical for tumor invasion and metastasis. Therefore, our research interests include:
- Elucidation of the signaling pathways impinged upon tumor invasion and metastasis.
- Identification and characterization of novel factors involved in protein translation initiation.
- Development and identification of novel agents or approaches for cancer therapeutics.
Experiencia relacionada con los ODS de las Naciones Unidas
En 2015, los estados miembros de las Naciones Unidas acordaron 17 Objetivos de Desarrollo Sostenible (ODS) para erradicar la pobreza, proteger el planeta y garantizar la prosperidad para todos. El trabajo de esta persona contribuye al logro de los siguientes ODS:
Cuantificación de educación / académica
Post Doctoral Fellow, SUNY of Buffalo
1999
Doctor of Philosophy, Arizona State University
1994
Master of Science, Tamkang Col.Of Arts And Sciences
1987
Bachelor of Science, Tamkang Col.Of Arts And Sciences
1985
Huella digital
- 1 Perfiles similares
Colaboraciones y áreas de investigación principales de los últimos cinco años
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Pdcd4-Rictor Interaction in Suppression of Lung Tumorigenesis
Yang, H.-S. (PI), Chen, L. (CoI), Fan, W.-M. (CoI), Hao, Z. (CoI), Lee, E. (CoI), Liu, X. (CoI) & Zhan, C.-G. (CoI)
9/20/23 → 8/31/28
Proyecto: Research project
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Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer
Liu, X. (PI), Allison, D. (CoI), Chen, L. (CoI) & Yang, H.-S. (CoPI)
7/1/23 → 6/30/28
Proyecto: Research project
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Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer
Yang, H.-S. (PI), Allison, D. (CoI), Chen, L. (CoI) & Liu, X. (CoPI)
7/1/23 → 6/30/28
Proyecto: Research project
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A Novel Peptide Suppresses Invasion and Metastasis in Rictor-amplified Lung Cancer
Yang, H.-S. (PI), Chen, M. (CoI) & Chen, L. (CoI)
Army Medical Research and Materiel Command
7/1/21 → 6/30/23
Proyecto: Research project
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A Novel Peptide to Inhibit Rictor-amplified Lung Tumorigenesis
Yang, H.-S. (PI), Arnold, S. M. (CoI), Chen, M. (CoI), Piecoro, D. (CoI), Wang, C. (CoI) & Wang, Q. (CoI)
7/1/18 → 6/30/21
Proyecto: Research project
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The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer
Zhang, Q., Peng, J., Zhang, Y., Liu, J., He, D., Zhao, Y., Wang, X., Li, C., Kong, Y., Wang, R., Mao, F., Wang, C., Wang, Q., Zhang, M., Wang, J., Yang, H. S. & Liu, X., mar 18 2025, En: Science Signaling. 18, 878, eadi5174.Producción científica: Article › revisión exhaustiva
Acceso abierto5 Citas (Scopus) -
Translational Inhibition of Slug by Pdcd4 Contributes to Invasion Inhibition in Colorectal Cancer Cells
Wang, Q., He, W., Han, S., Li, M., Wang, Y., Zaytseva, Y., Chen, L., Zhu, J. & Yang, H.-S., ago 2025, En: Cancer Medicine. 14, 15, p. e71145Producción científica: Article › revisión exhaustiva
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The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance
Wang, Q. & Yang, H. S., oct 2024, En: Pharmaceuticals. 17, 10, 1396.Producción científica: Review article › revisión exhaustiva
Acceso abierto1 Cita (Scopus) -
Dissecting the Roles of PDCD4 in Breast Cancer
Cai, Q., Yang, H. S., Li, Y. C. & Zhu, J., jun 20 2022, En: Frontiers in Oncology. 12, 855807.Producción científica: Review article › revisión exhaustiva
Acceso abierto32 Citas (Scopus) -
Emodin-8-O-β-D-glucopyranoside, a natural hydroxyanthraquinone glycoside from plant, suppresses cancer cell proliferation via p21-CDKs-Rb axis
Li, Y., Li, K., Zhao, Y., Li, Y., Li, D., Shen, L., Wang, Q., Yang, H. S. & Sun, Z., mar 1 2022, En: Toxicology and Applied Pharmacology. 438, 115909.Producción científica: Article › revisión exhaustiva
4 Citas (Scopus)