ADNI4: Alzheimer's Disease Neuroimaging Initiative 4

Alzheimer’s Disease Neuroimaging Initiative 4 (ADNI4) Richard King, MD Neurology Abstract 2.1 STUDY RATIONALE ADNI plays a central role in improving treatment trials. Since the study’s launch, ADNI Investigators with regulators in both the US and abroad have facilitated the design of major completed and ongoing drug trials. One of the most pressing challenges in the AD field, with immense scientific and ethical ramifications, is the chronic lack of ethnocultural, socio-economic, and educational diversity in research and trial populations, including in ADNI. ADNI4 aims to address this by enhancing recruitment of underrepresented populations (URPs). Another major challenge is the lack of efficient, scalable methods to identify cognitive impairment or those at risk for future impairment, in the population. ADNI4 addresses this using novel remote cohorts to assist with identifying, screening, and longitudinal monitoring of a large participant pool using remote, online cognitive assessments, and blood-based biomarker testing.