FY27 Continuation of KY Pediatric Inherited Cancer Risk Program

ABSTRACT Project Inherited Cancer Risk (PICR) is an IRB-approved clinical study that has been open at Kentucky Children’s Hospital (KCH) at the University of Kentucky (UK) since 2021 with a satellite program offered at Norton Children’s Hospital at the University of Louisville since 2025. The goal of PICR is to offer germline cancer predisposition screening to children, adolescents and young adults who have been diagnosed with pediatric cancer and who are patients of either KCH or Norton Children’s Hospital (NCH). This program involves NextGen focused exome sequencing for a panel of established cancer predisposition genes, an investigational panel of possible cancer predisposition genes along with optional inclusion of pharmacogenomic genes and bio banking for future research. A critical part of the project is the regular multidisciplinary statewide pediatric germline molecular tumor board to consider cases and make management recommendations. A panel of stakeholders from the cancer predisposition community including patients, caregivers, researchers, clinical care providers and advocates will be convened to provide feedback and input on the program and to develop content for a cancer predisposition symposium.