Minocycline in Amyotrophic Lateral Sclerosis

The purpose of this study is to determine whether the use of a high dose of minocycline slows the degeneration of neurons in patients with Amyotrophic Lateral Scierosis. This a multi-center double-blind study whose Principal Investigator is Dr. Paul H. Gordon of Columbia University. The study aims to have a total of 400 patients achieve randomization (the Month 4 visit); 200 will receive placebo and 200 will receive active minocycline. There are 13 study visits in total. Study procedures include blood tests, physical and neurological exams, muscle and breathing testing, and quality of life questionnaires. Dr. Gordon will be in charge of cond~cting the overall project and all site CQinvestigators shall work with him to'fulfill the objectives of the project. Eacb site investigator will be reSponsible for the supervision of the study visits, infonned consent procedures, source documentation, JRB approval, and regulatory documents at hislher site in accordance with the Manual of Operations, Good Clinical Practices, NIH guidelines, and FDA regulations.