TreaT NOW: Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome

TreaT NOW Thitinart Sithisarn, MD Abstract The goal of this observational, quasi-experimental research design is to emulate a randomized controlled trial using both retrospective and prospective data to assess the effectiveness of the primary pharmacologic agent for the treatment of NOWS. By leveraging real-world clinical data, we aim to generate causal insights that mimic the conditions of a randomized controlled trial while overcoming practical constraints.