TY - JOUR
T1 - α-Adrenoceptors and vascular regulation
T2 - Molecular, pharmacologic and clinical correlates
AU - Piascik, Michael T.
AU - Soltis, Edward E.
AU - Piascik, Mary M.
AU - Macmillan, Leigh B.
PY - 1996
Y1 - 1996
N2 - This manuscript is intended to provide a comprehensive review of the α-adrenoceptors (APs) and their role in vascular regulation. The historical development of the concept of receptors and the division of the α-ARs into α1 and α2 subtypes is traced. Emphasis will be placed on current understanding of the specific contribution of discrete α1- and α2-AR subtypes in the regulation of the vasculature, selective agonists and antagonists for these receptors, the second messengers utilized by these receptors, the myoplasmic calcium pathways activated to initiate smooth muscle contraction, as well as the clinical uses of agonists and antagonists that work at these receptors. New information is presented that deals with the molecular aspects of ligand interactions with specific subdomains of these receptors, as well as mRNA distribution and the regulation of α1- and α2-AR gene transcription and translation.
AB - This manuscript is intended to provide a comprehensive review of the α-adrenoceptors (APs) and their role in vascular regulation. The historical development of the concept of receptors and the division of the α-ARs into α1 and α2 subtypes is traced. Emphasis will be placed on current understanding of the specific contribution of discrete α1- and α2-AR subtypes in the regulation of the vasculature, selective agonists and antagonists for these receptors, the second messengers utilized by these receptors, the myoplasmic calcium pathways activated to initiate smooth muscle contraction, as well as the clinical uses of agonists and antagonists that work at these receptors. New information is presented that deals with the molecular aspects of ligand interactions with specific subdomains of these receptors, as well as mRNA distribution and the regulation of α1- and α2-AR gene transcription and translation.
KW - ligand-α-AR interactions, vascular smooth muscle regulation by α-ARs
KW - therapeutic use of α-AR agonists and antagonists
KW - α- and α-AR subtypes, α-AR subtype cloning
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U2 - 10.1016/S0163-7258(96)00117-9
DO - 10.1016/S0163-7258(96)00117-9
M3 - Review article
C2 - 9364576
AN - SCOPUS:0030446899
SN - 0163-7258
VL - 72
SP - 215
EP - 241
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 3
ER -