Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models

Hai qiong Zheng; Jia bing Rong; Fei ming Ye; Yin chuan Xu; Hong S. Lu; Jian an Wang

doi:10.1631/jzus.B2000022

Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models

Hai qiong Zheng
, Jia bing Rong
, Fei ming Ye
, Yin chuan Xu
, Hong S. Lu
, Jian an Wang

Producción científica: Review article › revisión exhaustiva

41 Citas (Scopus)

Resumen

Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.

Título traducido de la contribución	Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
Idioma original	English
Páginas (desde-hasta)	603-610
Número de páginas	8
Publicación	Journal of Zhejiang University: Science B
Volumen	21
N.º	8
DOI	https://doi.org/10.1631/jzus.B2000022
Estado	Published - ago 1 2020

Nota bibliográfica

Publisher Copyright:
© 2020, Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature.

Financiación

Project supported by the National Natural Science Foundation of China (Nos. 81870292 and 81971860) and the National Key Research and Development Program of China (No. 2016YFC1301204) Acknowledgments

Financiadores	Número del financiador
National Natural Science Foundation of China (NSFC)	81870292, 81971860
National Natural Science Foundation of China (NSFC)
National Key Basic Research and Development Program of China	2016YFC1301204
National Key Basic Research and Development Program of China

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Veterinary
General Pharmacology, Toxicology and Pharmaceutics

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10.1631/jzus.B2000022

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abstract = "Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.",

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AU - Ye, Fei ming

AU - Xu, Yin chuan

AU - Lu, Hong S.

AU - Wang, Jian an

PY - 2020/8/1

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Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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