A convenient procedure for parallel ester hydrolysis

Marc O. Anderson; Jamie Moser; John Sherrill; R. Kiplin Guy

doi:10.1055/s-2004-832828

A convenient procedure for parallel ester hydrolysis

Marc O. Anderson
, Jamie Moser
, John Sherrill
, R. Kiplin Guy

Producción científica: Article › revisión exhaustiva

16 Citas (Scopus)

Resumen

The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.

Idioma original	English
Páginas (desde-hasta)	2391-2393
Número de páginas	3
Publicación	Synlett
N.º	13
DOI	https://doi.org/10.1055/s-2004-832828
Estado	Published - nov 3 2004

ASJC Scopus subject areas

Organic Chemistry

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@article{704ac3e6f20f45e39b46ca2009bf1752,

title = "A convenient procedure for parallel ester hydrolysis",

abstract = "The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.",

keywords = "9-Chloroacridine, Barium hydroxide octahydrate, Deprotection, Ester hydrolysis, Parallel synthesis",

author = "Anderson, \{Marc O.\} and Jamie Moser and John Sherrill and Guy, \{R. Kiplin\}",

year = "2004",

month = nov,

day = "3",

doi = "10.1055/s-2004-832828",

language = "English",

pages = "2391--2393",

number = "13",

}

TY - JOUR

T1 - A convenient procedure for parallel ester hydrolysis

AU - Anderson, Marc O.

AU - Moser, Jamie

AU - Sherrill, John

AU - Guy, R. Kiplin

PY - 2004/11/3

Y1 - 2004/11/3

N2 - The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.

AB - The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.

KW - 9-Chloroacridine

KW - Barium hydroxide octahydrate

KW - Deprotection

KW - Ester hydrolysis

KW - Parallel synthesis

UR - https://www.scopus.com/pages/publications/8644275496

UR - https://www.scopus.com/pages/publications/8644275496#tab=citedBy

U2 - 10.1055/s-2004-832828

DO - 10.1055/s-2004-832828

M3 - Article

AN - SCOPUS:8644275496

SN - 0936-5214

SP - 2391

EP - 2393

JO - Synlett

JF - Synlett

IS - 13

ER -

A convenient procedure for parallel ester hydrolysis

Resumen

ASJC Scopus subject areas

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