A cross-sectional examination of the early-onset hypertensive disorders of pregnancy and industrial emissions of toxic metals using Kentucky birth records, 2008–2017

Courtney J. Walker; W. Jay Christian; Anna Kucharska-Newton; Steven R. Browning

doi:10.1371/journal.pone.0274250

A cross-sectional examination of the early-onset hypertensive disorders of pregnancy and industrial emissions of toxic metals using Kentucky birth records, 2008–2017

Courtney J. Walker, W. Jay Christian, Anna Kucharska-Newton, Steven R. Browning

Producción científica: Article › revisión exhaustiva

2 Citas (Scopus)

Resumen

This cross-sectional study assessed geospatial patterns of early-onset hypertensive disorders of pregnancy (eHDP) in primiparous mothers and exposure to industrial emissions using geocoded residential information from Kentucky live (N = 210,804) and still (N = 1,247) birth records (2008–2017) and census block group estimates of aerosol concentrations of arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), selenium (Se), and zinc (Zi) from the Risk Screening Environmental Indicators (RSEI) model. A latent class analysis allowed for the identification of four district exposure classes—As, Cd, and Pb (12.6%); Se and Zi (21.4%); Pb and Cr (8%); and low or no exposures (57.9%). Women classified as having a high probability of exposure to both Pb and Cr had a statistically significantly greater prevalence of eHDP after adjusting for demographic factors (aPR = 1.22, 95% CI: 1.04, 1.44) relative to those with low or no exposure. Our findings contribute to the emerging literature on the association of metal exposures with pregnancy outcomes.

Idioma original	English
Número de artículo	e0274250
Publicación	PLoS ONE
Volumen	17
N.º	9 September
DOI	https://doi.org/10.1371/journal.pone.0274250
Estado	Published - sept 2022

Nota bibliográfica

Publisher Copyright:
© 2022 Walker et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Financiación

This manuscript was supported in part by the Education Research Center (ERC) through Grant 6U54OH007547 (CJW) and by Berea College through the Olive Ruth Russel Fellowship (CJW). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIOSH/CDC or Berea College. This manuscript was supported in part by the Education Research Center (ERC) through Grant 6U54OH007547 (CJW) and by Berea College through the Olive Ruth Russel Fellowship (CJW). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIOSH/CDC or Berea College. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Financiadores	Número del financiador
Berea College
NIOSH Education and Research Center	6U54OH007547
Centers for Disease Control and Prevention
National Institute for Occupational Safety and Health

ASJC Scopus subject areas

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title = "A cross-sectional examination of the early-onset hypertensive disorders of pregnancy and industrial emissions of toxic metals using Kentucky birth records, 2008–2017",

abstract = "This cross-sectional study assessed geospatial patterns of early-onset hypertensive disorders of pregnancy (eHDP) in primiparous mothers and exposure to industrial emissions using geocoded residential information from Kentucky live (N = 210,804) and still (N = 1,247) birth records (2008–2017) and census block group estimates of aerosol concentrations of arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), selenium (Se), and zinc (Zi) from the Risk Screening Environmental Indicators (RSEI) model. A latent class analysis allowed for the identification of four district exposure classes—As, Cd, and Pb (12.6\%); Se and Zi (21.4\%); Pb and Cr (8\%); and low or no exposures (57.9\%). Women classified as having a high probability of exposure to both Pb and Cr had a statistically significantly greater prevalence of eHDP after adjusting for demographic factors (aPR = 1.22, 95\% CI: 1.04, 1.44) relative to those with low or no exposure. Our findings contribute to the emerging literature on the association of metal exposures with pregnancy outcomes.",

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A cross-sectional examination of the early-onset hypertensive disorders of pregnancy and industrial emissions of toxic metals using Kentucky birth records, 2008–2017

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