A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

Yoshimi Tsuda; Christopher J. Parkins; Patrizia Caposio; Friederike Feldmann; Sara Botto; Susan Ball; Ilhem Messaoudi; Luka Cicin-Sain; Heinz Feldmann; Michael A. Jarvis

doi:10.1016/j.vaccine.2015.03.029

A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

Yoshimi Tsuda
, Christopher J. Parkins
, Patrizia Caposio
, Friederike Feldmann
, Sara Botto
, Susan Ball
, Ilhem Messaoudi
, Luka Cicin-Sain
, Heinz Feldmann
, Michael A. Jarvis

Producción científica: Article › revisión exhaustiva

54 Citas (Scopus)

Resumen

Ebola virus (Zaire ebolavirus; EBOV) is a highly lethal hemorrhagic disease virus that most recently was responsible for two independent 2014 outbreaks in multiple countries in Western Africa, and the Democratic Republic of the Congo, respectively. Herein, we show that a cytomegalovirus (CMV)-based vaccine provides durable protective immunity from Ebola virus following a single vaccine dose. This study has implications for human vaccination against ebolaviruses, as well as for development of a 'disseminating' vaccine to target these viruses in wild African great apes.

Idioma original	English
Páginas (desde-hasta)	2261-2266
Número de páginas	6
Publicación	Vaccine
Volumen	33
N.º	19
DOI	https://doi.org/10.1016/j.vaccine.2015.03.029
Estado	Published - may 1 2015

Nota bibliográfica

Publisher Copyright:
© 2015 Elsevier Ltd.

Financiación

We thank Dr U. Koszinowski (Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Germany) for providing the pSMfr3 MCMV BAC, and Dr D. Court (NCI-Frederick, MD) for providing the lambda-based recombination system used to construct the original MCMV/ZEBOV-NP CTL construct. We appreciate K. Marshall (VGTI, OR) and J. Bailey (NIAID, MT) for their organization and coordination of animals used in the study. We also thank the members of Rocky Mountain Veterinary Branch (DIR, NIAID , NIH) for assistance with animal care. Finally, we thank Drs H. Ebihara (DIR, NIAID , NIH), A. Marzi (DIR, NIAID , NIH), P. Barry (University of California at Davis, CA), M. Cranfield (Mountain Gorilla Veterinary Project, Baltimore, MD) for insightful discussions. This study was supported by R21 (AI088442) and the Intramural Research Program of the NIAID , NIH ; and University of Plymouth, School of Biomedical and Healthcare Sciences internal funding.

Financiadores	Número del financiador
National Institutes of Health (NIH)
Plymouth Marjon University
National Institute of Allergy and Infectious F32-AI286447 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI168214 Jason W. Rosch Diseases National Institute of Allergy and Infectious P30 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R00-AI166116 Christopher D. Radka Diseases National Institute of Allergy and Infectious T32-AI106700 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI192221 Jason W. Rosch Diseases National Inst...	ZIAAI001089, R21AI088442

ODS de las Naciones Unidas

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Good health and well being

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2015.03.029

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title = "A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose",

abstract = "Ebola virus (Zaire ebolavirus; EBOV) is a highly lethal hemorrhagic disease virus that most recently was responsible for two independent 2014 outbreaks in multiple countries in Western Africa, and the Democratic Republic of the Congo, respectively. Herein, we show that a cytomegalovirus (CMV)-based vaccine provides durable protective immunity from Ebola virus following a single vaccine dose. This study has implications for human vaccination against ebolaviruses, as well as for development of a 'disseminating' vaccine to target these viruses in wild African great apes.",

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AU - Botto, Sara

AU - Ball, Susan

AU - Messaoudi, Ilhem

AU - Cicin-Sain, Luka

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AU - Jarvis, Michael A.

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A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

Resumen

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Financiación

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ASJC Scopus subject areas

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