A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Erin Wachter; Brock S. Howerton; Emily C. Hall; Sean Parkin; Edith C. Glazer

doi:10.1039/c3cc47269h

A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Erin Wachter
, Brock S. Howerton
, Emily C. Hall
, Sean Parkin
, Edith C. Glazer

Chemistry

Producción científica: Article › revisión exhaustiva

69 Citas (Scopus)

Resumen

Ru(bpy)₂dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

Idioma original	English
Páginas (desde-hasta)	311-313
Número de páginas	3
Publicación	Chemical Communications
Volumen	50
N.º	3
DOI	https://doi.org/10.1039/c3cc47269h
Estado	Published - dic 3 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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A new type of DNA “light-switch”: A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

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