A Potential Role of Phospholipase 2 Group IIA (PLA2-IIA) in P. gingivalis-Induced Oral Dysbiosis

Octavio A. Gonzalez; Vanessa Euzebio-Alves; Yelena Alimova; Ahmad Al-Attar; J. L. Ebersole

doi:10.1007/978-3-030-28524-1_7

A Potential Role of Phospholipase 2 Group IIA (PLA₂-IIA) in P. gingivalis-Induced Oral Dysbiosis

Octavio A. Gonzalez
, Vanessa Euzebio-Alves
, Yelena Alimova
, Ahmad Al-Attar
, J. L. Ebersole

Producción científica: Chapter › revisión exhaustiva

4 Citas (Scopus)

Resumen

Porphyromonas gingivalis is an oral pathogen with the ability to induce oral dysbiosis and periodontal disease. Nevertheless, the mechanisms by which P. gingivalis could abrogate the host–microbe symbiotic relationship leading to oral dysbiosis remain unclear. We have recently demonstrated that P. gingivalis specifically increased the antimicrobial properties of oral epithelial cells, through a strong induction of the expression of PLA₂-IIA in a mechanism that involves activation of the Notch-1 receptor. Moreover, gingival expression of PLA₂-IIA was significantly increased during initiation and progression of periodontal disease in non-human primates and interestingly, those PLA₂-IIA expression changes were concurrent with oral dysbiosis. In this chapter, we present an innovative hypothesis of a potential mechanism involved in P. gingivalis-induced oral dysbiosis and inflammation based on our previous observations and a robust body of literature that supports the antimicrobial and proinflammatory properties of PLA₂-IIA as well as its role in other chronic inflammatory diseases.

Idioma original	English
Título de la publicación alojada	Advances in Experimental Medicine and Biology
Páginas	79-95
Número de páginas	17
DOI	https://doi.org/10.1007/978-3-030-28524-1_7
Estado	Published - 2019

Serie de la publicación

Nombre	Advances in Experimental Medicine and Biology
Volumen	1197
ISSN (versión impresa)	0065-2598
ISSN (versión digital)	2214-8019

Nota bibliográfica

Publisher Copyright:
© 2019, Springer Nature Switzerland AG.

Financiación

Findings reported in this review were funded by NIH/NIDCR grant DE024804, NIH/ NIGMS P20GM103538 and College of Dentistry University of Kentucky. We thank Drs. Yongzheng Wu and Lhousseine Touqi from Institute Pasteur for kindly sharing the hPLA2-IIA-Tg mice as well as Drs. Jorge Frias (U. of Florida) and Sreenatha Kirakodu (U. of Kentucky) for their support in oral microbiome preliminary analysis. We also are grateful to Dr. Brittany Camenisch and Division of Periodontology for supporting the ongoing preliminary clinical study in salivary PLA2-IIA levels.

Financiadores	Número del financiador
University of Kentucky College of Dentistry Division of Periodontology
NIH/NIDCR	DE024804, NIH/ NIGMS P20GM103538
University of Kentucky College of Dentistry	Kentucky

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Acceder al documento

10.1007/978-3-030-28524-1_7

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abstract = "Porphyromonas gingivalis is an oral pathogen with the ability to induce oral dysbiosis and periodontal disease. Nevertheless, the mechanisms by which P. gingivalis could abrogate the host–microbe symbiotic relationship leading to oral dysbiosis remain unclear. We have recently demonstrated that P. gingivalis specifically increased the antimicrobial properties of oral epithelial cells, through a strong induction of the expression of PLA2-IIA in a mechanism that involves activation of the Notch-1 receptor. Moreover, gingival expression of PLA2-IIA was significantly increased during initiation and progression of periodontal disease in non-human primates and interestingly, those PLA2-IIA expression changes were concurrent with oral dysbiosis. In this chapter, we present an innovative hypothesis of a potential mechanism involved in P. gingivalis-induced oral dysbiosis and inflammation based on our previous observations and a robust body of literature that supports the antimicrobial and proinflammatory properties of PLA2-IIA as well as its role in other chronic inflammatory diseases.",

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AB - Porphyromonas gingivalis is an oral pathogen with the ability to induce oral dysbiosis and periodontal disease. Nevertheless, the mechanisms by which P. gingivalis could abrogate the host–microbe symbiotic relationship leading to oral dysbiosis remain unclear. We have recently demonstrated that P. gingivalis specifically increased the antimicrobial properties of oral epithelial cells, through a strong induction of the expression of PLA2-IIA in a mechanism that involves activation of the Notch-1 receptor. Moreover, gingival expression of PLA2-IIA was significantly increased during initiation and progression of periodontal disease in non-human primates and interestingly, those PLA2-IIA expression changes were concurrent with oral dysbiosis. In this chapter, we present an innovative hypothesis of a potential mechanism involved in P. gingivalis-induced oral dysbiosis and inflammation based on our previous observations and a robust body of literature that supports the antimicrobial and proinflammatory properties of PLA2-IIA as well as its role in other chronic inflammatory diseases.

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