A working model for the type III secretion mechanism in Chlamydia

Joshua C. Ferrell; Kenneth A. Fields

doi:10.1016/j.micinf.2015.10.006

A working model for the type III secretion mechanism in Chlamydia

Joshua C. Ferrell, Kenneth A. Fields

Microbiology, Immunology, and Molecular Genetics

Producción científica: Short survey › revisión exhaustiva

34 Citas (Scopus)

Resumen

It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model herein that is based on current evidence.

Idioma original	English
Páginas (desde-hasta)	84-92
Número de páginas	9
Publicación	Microbes and Infection
Volumen	18
N.º	2
DOI	https://doi.org/10.1016/j.micinf.2015.10.006
Estado	Published - feb 1 2016

Nota bibliográfica

Publisher Copyright:
© 2015 Institut Pasteur.

Financiación

KAF is supported by a Public Health Service grant from the National Institutes of Health , NIAID ( AI0065530 ).

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases	AI0065530, R01AI065530
U.S. Public Health Service

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

ODS de las Naciones Unidas

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10.1016/j.micinf.2015.10.006

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title = "A working model for the type III secretion mechanism in Chlamydia",

abstract = "It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model herein that is based on current evidence.",

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author = "Ferrell, \{Joshua C.\} and Fields, \{Kenneth A.\}",

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AU - Fields, Kenneth A.

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N2 - It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model herein that is based on current evidence.

AB - It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model herein that is based on current evidence.

KW - Effector

KW - Pathogenesis

KW - Secretion

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U2 - 10.1016/j.micinf.2015.10.006

DO - 10.1016/j.micinf.2015.10.006

M3 - Short survey

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AN - SCOPUS:84957843455

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VL - 18

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EP - 92

JO - Microbes and Infection

JF - Microbes and Infection

IS - 2

ER -

A working model for the type III secretion mechanism in Chlamydia

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

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