TY - JOUR
T1 - ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents
AU - Bhatt, Deepak L.
AU - Scheiman, James
AU - Abraham, Neena S.
AU - Antman, Elliott M.
AU - Chan, Francis K.L.
AU - Furberg, Curt D.
AU - Johnson, David A.
AU - Mahaffey, Kenneth W.
AU - Quigley, Eamonn M.
AU - Harrington, Robert A.
AU - Bates, Eric R.
AU - Bridges, Charles R.
AU - Eisenberg, Mark J.
AU - Ferrari, Victor A.
AU - Hlatky, Mark A.
AU - Kaul, Sanjay
AU - Lindner, Jonathan R.
AU - Moliterno, David J.
AU - Mukherjee, Debabrata
AU - Schofield, Richard S.
AU - Rosenson, Robert S.
AU - Stein, James H.
AU - Weitz, Howard H.
AU - Wesley, Deborah J.
PY - 2008/10/28
Y1 - 2008/10/28
N2 - In appropriate patients oral antiplatelet therapy decreases ischemic risks, but this therapy may increase bleeding complications. Of the major bleeding that occurs, the largest proportion is due to GI hemorrhage. Concomitant use of NSAIDs further raises the risk of GI bleeding. Gastroprotection strategies consist of use of PPIs in patients at high risk of GI bleeding and eradication of H. pylori in patients with a history of ulcers. Communication between cardiologists, gastroenterologists, and primary care physicians is critical to weigh the ischemic and bleeding risks in an individual patient who needs antiplatelet therapy but who is at risk for or develops significant GI bleeding.
AB - In appropriate patients oral antiplatelet therapy decreases ischemic risks, but this therapy may increase bleeding complications. Of the major bleeding that occurs, the largest proportion is due to GI hemorrhage. Concomitant use of NSAIDs further raises the risk of GI bleeding. Gastroprotection strategies consist of use of PPIs in patients at high risk of GI bleeding and eradication of H. pylori in patients with a history of ulcers. Communication between cardiologists, gastroenterologists, and primary care physicians is critical to weigh the ischemic and bleeding risks in an individual patient who needs antiplatelet therapy but who is at risk for or develops significant GI bleeding.
KW - ACCF Expert Consensus Document
KW - NSAID
KW - antiplatelet therapy
KW - aspirin
KW - gastroduodenal ulcer
KW - gastrointestinal bleeding
KW - gastrointestinal risk
KW - stents
KW - thrombosis
UR - https://www.scopus.com/pages/publications/54049118496
UR - https://www.scopus.com/pages/publications/54049118496#tab=citedBy
U2 - 10.1016/j.jacc.2008.08.002
DO - 10.1016/j.jacc.2008.08.002
M3 - Review article
C2 - 19017521
AN - SCOPUS:54049118496
SN - 0735-1097
VL - 52
SP - 1502
EP - 1517
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 18
ER -