Activation analysis in a multitechnique study of trace element imbalances in age-related neurological diseases

W. D. Ehmann; X. X. Ding; S. S. Khare; M. A. Lovell; B. F. Ni; L. Tandon; D. E. Vance; D. E. Wenstrup

doi:10.1007/BF02040894

Activation analysis in a multitechnique study of trace element imbalances in age-related neurological diseases

W. D. Ehmann
, X. X. Ding
, S. S. Khare
, M. A. Lovell
, B. F. Ni
, L. Tandon
, D. E. Vance
, D. E. Wenstrup

Producción científica: Article › revisión exhaustiva

6 Citas (Scopus)

Resumen

It has been suggested that several age-related neurological diseases such as Alzheimer's disease and amyotrophic lateral sclerosis may be related to environmental toxins. Bulk sample multielement analyses by INAA alone are not adequate to define the role of trace elements in these diseases. A multitechnique approach has been developed that incorporates 14 MeV, instrumental reactor, radiochemical, and pre-irradiation chemical neutron activation analysis, together with laser microprobe mass spectrometry. The analytical scheme is able to provide bulk or protein normalized elemental concentrations, as well as microstructural, cellular, and subcellular localization information.

Idioma original	English
Páginas (desde-hasta)	223-231
Número de páginas	9
Publicación	Journal of Radioanalytical and Nuclear Chemistry Articles
Volumen	168
N.º	1
DOI	https://doi.org/10.1007/BF02040894
Estado	Published - feb 1993

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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abstract = "It has been suggested that several age-related neurological diseases such as Alzheimer's disease and amyotrophic lateral sclerosis may be related to environmental toxins. Bulk sample multielement analyses by INAA alone are not adequate to define the role of trace elements in these diseases. A multitechnique approach has been developed that incorporates 14 MeV, instrumental reactor, radiochemical, and pre-irradiation chemical neutron activation analysis, together with laser microprobe mass spectrometry. The analytical scheme is able to provide bulk or protein normalized elemental concentrations, as well as microstructural, cellular, and subcellular localization information.",

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AU - Ding, X. X.

AU - Khare, S. S.

AU - Lovell, M. A.

AU - Ni, B. F.

AU - Tandon, L.

AU - Vance, D. E.

AU - Wenstrup, D. E.

PY - 1993/2

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AB - It has been suggested that several age-related neurological diseases such as Alzheimer's disease and amyotrophic lateral sclerosis may be related to environmental toxins. Bulk sample multielement analyses by INAA alone are not adequate to define the role of trace elements in these diseases. A multitechnique approach has been developed that incorporates 14 MeV, instrumental reactor, radiochemical, and pre-irradiation chemical neutron activation analysis, together with laser microprobe mass spectrometry. The analytical scheme is able to provide bulk or protein normalized elemental concentrations, as well as microstructural, cellular, and subcellular localization information.

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JF - Journal of Radioanalytical and Nuclear Chemistry Articles

IS - 1

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Activation analysis in a multitechnique study of trace element imbalances in age-related neurological diseases

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ASJC Scopus subject areas

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