Activation of the hedgehog pathway in a subset of lung cancers

Sumin Chi; Shuhong Huang; Chengxin Li; Xiaoli Zhang; Nonggao He; Manoop S. Bhutani; Dennie Jones; Claudia Y. Castro; Roberto Logrono; Abida Haque; Joseph Zwischenberger; Stephen K. Tyring; Hongwei Zhang; Jingwu Xie

doi:10.1016/j.canlet.2005.11.036

Activation of the hedgehog pathway in a subset of lung cancers

Sumin Chi
, Shuhong Huang
, Chengxin Li
, Xiaoli Zhang
, Nonggao He
, Manoop S. Bhutani
, Dennie Jones
, Claudia Y. Castro
, Roberto Logrono
, Abida Haque
, Joseph Zwischenberger
, Stephen K. Tyring
, Hongwei Zhang
, Jingwu Xie

Producción científica: Article › revisión exhaustiva

52 Citas (Scopus)

Resumen

Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.

Idioma original	English
Páginas (desde-hasta)	53-60
Número de páginas	8
Publicación	Cancer Letters
Volumen	244
N.º	1
DOI	https://doi.org/10.1016/j.canlet.2005.11.036
Estado	Published - nov 28 2006

Nota bibliográfica

Funding Information:
This research was supported by grants from the NIH (R01-CA94160, JX), Department of Defense (DOD-PC030429, JX), the NIEHS (ES06676) and National Science Foundation of China (30228031, JX and HWZ).

Financiación

This research was supported by grants from the NIH (R01-CA94160, JX), Department of Defense (DOD-PC030429, JX), the NIEHS (ES06676) and National Science Foundation of China (30228031, JX and HWZ).

Financiadores	Número del financiador
National Institutes of Health (NIH)
U.S. Department of Defense	DOD-PC030429
U.S. Department of Defense
National Childhood Cancer Registry – National Cancer Institute	R01CA094160
National Childhood Cancer Registry – National Cancer Institute
National Institutes of Health/National Institute of Environmental Health Sciences	ES06676
National Institutes of Health/National Institute of Environmental Health Sciences
National Natural Science Foundation of China (NSFC)	30228031
National Natural Science Foundation of China (NSFC)

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2005.11.036

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title = "Activation of the hedgehog pathway in a subset of lung cancers",

abstract = "Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10\% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.",

keywords = "Gli1, Hedgehog, Lung cancer, PTCH1, Su(Fu)",

author = "Sumin Chi and Shuhong Huang and Chengxin Li and Xiaoli Zhang and Nonggao He and Bhutani, \{Manoop S.\} and Dennie Jones and Castro, \{Claudia Y.\} and Roberto Logrono and Abida Haque and Joseph Zwischenberger and Tyring, \{Stephen K.\} and Hongwei Zhang and Jingwu Xie",

note = "Funding Information: This research was supported by grants from the NIH (R01-CA94160, JX), Department of Defense (DOD-PC030429, JX), the NIEHS (ES06676) and National Science Foundation of China (30228031, JX and HWZ). ",

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doi = "10.1016/j.canlet.2005.11.036",

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AU - Chi, Sumin

AU - Huang, Shuhong

AU - Li, Chengxin

AU - Zhang, Xiaoli

AU - He, Nonggao

AU - Bhutani, Manoop S.

AU - Jones, Dennie

AU - Castro, Claudia Y.

AU - Logrono, Roberto

AU - Haque, Abida

AU - Zwischenberger, Joseph

AU - Tyring, Stephen K.

AU - Zhang, Hongwei

AU - Xie, Jingwu

N1 - Funding Information: This research was supported by grants from the NIH (R01-CA94160, JX), Department of Defense (DOD-PC030429, JX), the NIEHS (ES06676) and National Science Foundation of China (30228031, JX and HWZ).

PY - 2006/11/28

Y1 - 2006/11/28

N2 - Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.

AB - Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.

KW - Gli1

KW - Hedgehog

KW - Lung cancer

KW - PTCH1

KW - Su(Fu)

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VL - 244

SP - 53

EP - 60

JO - Cancer Letters

JF - Cancer Letters

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Activation of the hedgehog pathway in a subset of lung cancers

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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