Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

Lalit Kumar Sharma; Na Ra Lee; Eun Ryoung Jang; Beilei Lei; Chang Guo Zhan; Wooin Lee; Kyung Bo Kim

doi:10.1002/cbic.201200307

Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

Lalit Kumar Sharma
, Na Ra Lee
, Eun Ryoung Jang
, Beilei Lei
, Chang Guo Zhan
, Wooin Lee
, Kyung Bo Kim

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

15 Citas (Scopus)

Resumen

Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

Idioma original	English
Páginas (desde-hasta)	1899-1903
Número de páginas	5
Publicación	ChemBioChem
Volumen	13
N.º	13
DOI	https://doi.org/10.1002/cbic.201200307
Estado	Published - sept 3 2012

Financiación

Financiadores	Número del financiador
National Childhood Cancer Registry – National Cancer Institute	R01CA128903

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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10.1002/cbic.201200307

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abstract = "Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.",

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AU - Sharma, Lalit Kumar

AU - Lee, Na Ra

AU - Jang, Eun Ryoung

AU - Lei, Beilei

AU - Zhan, Chang Guo

AU - Lee, Wooin

AU - Kim, Kyung Bo

PY - 2012/9/3

Y1 - 2012/9/3

N2 - Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

AB - Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

KW - Activity-based probes

KW - Immunoproteasome

KW - Near-infrared fluorescent probes

KW - Proteomics

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UR - https://www.scopus.com/pages/publications/84865568776#tab=citedBy

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Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

Resumen

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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