Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue

Edward D. Hall; J. Mark Braughler

doi:10.1016/0014-4886(81)90067-4

Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue

Edward D. Hall, J. Mark Braughler

Neuroscience

Producción científica: Article › revisión exhaustiva

119 Citas (Scopus)

Resumen

The effects of a large intravenous dose of the glucocorticoid methylprednisolone on lipid peroxide formation in cat lumbar spinal cord homogenate was examined using the thiobarbituric acid test for malonyldialdehyde production. One hour after the injection of a 30-mg/kg dose of methylprednisolone, lipid peroxidation was reduced by more than a third. After a 90-mg/kg glucocorticoid dose, an opposite effect was observed; the formation of malonyldialdehyde was actually increased by more than 55%. These data demonstrate that glucocorticoid may either decrease or increase central nervous system lipid peroxidation as a function of dose. These results have possible clinical neurological implications.

Idioma original	English
Páginas (desde-hasta)	321-324
Número de páginas	4
Publicación	Experimental Neurology
Volumen	73
N.º	1
DOI	https://doi.org/10.1016/0014-4886(81)90067-4
Estado	Published - jul 1981

Nota bibliográfica

Funding Information:
Abbreviations: MP-methylprednisolone sodium succinate, MDA-malonyldialdehyde. ’ The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman and a gift of methylprednisolone sodium succinate (Solu-Medrol) from the Upjohn Co., Kalamazoo, Michigan. This research was supported by a grant to E.D.H. from the Amyotrophic Lateral Sclerosis Society of America. Address all correspondence to E.D.H.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Financiación

Abbreviations: MP-methylprednisolone sodium succinate, MDA-malonyldialdehyde. ’ The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman and a gift of methylprednisolone sodium succinate (Solu-Medrol) from the Upjohn Co., Kalamazoo, Michigan. This research was supported by a grant to E.D.H. from the Amyotrophic Lateral Sclerosis Society of America. Address all correspondence to E.D.H.

Financiadores	Número del financiador
Hennepin Faculty Associates Amyotrophic Lateral Sclerosis Association Certified ALS Center

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/0014-4886(81)90067-4

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title = "Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue",

abstract = "The effects of a large intravenous dose of the glucocorticoid methylprednisolone on lipid peroxide formation in cat lumbar spinal cord homogenate was examined using the thiobarbituric acid test for malonyldialdehyde production. One hour after the injection of a 30-mg/kg dose of methylprednisolone, lipid peroxidation was reduced by more than a third. After a 90-mg/kg glucocorticoid dose, an opposite effect was observed; the formation of malonyldialdehyde was actually increased by more than 55\%. These data demonstrate that glucocorticoid may either decrease or increase central nervous system lipid peroxidation as a function of dose. These results have possible clinical neurological implications.",

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AU - Braughler, J. Mark

N1 - Funding Information: Abbreviations: MP-methylprednisolone sodium succinate, MDA-malonyldialdehyde. ’ The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman and a gift of methylprednisolone sodium succinate (Solu-Medrol) from the Upjohn Co., Kalamazoo, Michigan. This research was supported by a grant to E.D.H. from the Amyotrophic Lateral Sclerosis Society of America. Address all correspondence to E.D.H. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

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N2 - The effects of a large intravenous dose of the glucocorticoid methylprednisolone on lipid peroxide formation in cat lumbar spinal cord homogenate was examined using the thiobarbituric acid test for malonyldialdehyde production. One hour after the injection of a 30-mg/kg dose of methylprednisolone, lipid peroxidation was reduced by more than a third. After a 90-mg/kg glucocorticoid dose, an opposite effect was observed; the formation of malonyldialdehyde was actually increased by more than 55%. These data demonstrate that glucocorticoid may either decrease or increase central nervous system lipid peroxidation as a function of dose. These results have possible clinical neurological implications.

AB - The effects of a large intravenous dose of the glucocorticoid methylprednisolone on lipid peroxide formation in cat lumbar spinal cord homogenate was examined using the thiobarbituric acid test for malonyldialdehyde production. One hour after the injection of a 30-mg/kg dose of methylprednisolone, lipid peroxidation was reduced by more than a third. After a 90-mg/kg glucocorticoid dose, an opposite effect was observed; the formation of malonyldialdehyde was actually increased by more than 55%. These data demonstrate that glucocorticoid may either decrease or increase central nervous system lipid peroxidation as a function of dose. These results have possible clinical neurological implications.

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Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue

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