Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone

J. Mark Braughler; Edward D. Hall

doi:10.1016/0006-8993(81)90311-5

Acute enhancement of spinal cord synaptosomal (Na⁺ + K⁺)-ATPase activity in cats following intravenous methylprednisolone

J. Mark Braughler
, Edward D. Hall

Neuroscience

Producción científica: Article › revisión exhaustiva

44 Citas (Scopus)

Resumen

The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na⁺ + K⁺)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na⁺ + K⁺)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.

Idioma original	English
Páginas (desde-hasta)	464-469
Número de páginas	6
Publicación	Brain Research
Volumen	219
N.º	2
DOI	https://doi.org/10.1016/0006-8993(81)90311-5
Estado	Published - ago 31 1981

Nota bibliográfica

Funding Information:
Methylprednisolone (sodium succinate; Solu-Medrol) was generously supplied by the UpJohn Co., Kalamazoo, Mich. The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman. This work was supported by grants to E.D.H. from the National Institute of Mental Health (MH-34111) and the Amyotrophic Lateral Sclerosis Society of America and a Biomedical Research Development Grant (RR 09026) to J.M.B.

Financiación

Methylprednisolone (sodium succinate; Solu-Medrol) was generously supplied by the UpJohn Co., Kalamazoo, Mich. The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman. This work was supported by grants to E.D.H. from the National Institute of Mental Health (MH-34111) and the Amyotrophic Lateral Sclerosis Society of America and a Biomedical Research Development Grant (RR 09026) to J.M.B.

Financiadores	Número del financiador
National Institute of Mental Health	MH-34111
Hennepin Faculty Associates Amyotrophic Lateral Sclerosis Association Certified ALS Center	RR 09026

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(81)90311-5

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title = "Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone",

abstract = "The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.",

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note = "Funding Information: Methylprednisolone (sodium succinate; Solu-Medrol) was generously supplied by the UpJohn Co., Kalamazoo, Mich. The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman. This work was supported by grants to E.D.H. from the National Institute of Mental Health (MH-34111) and the Amyotrophic Lateral Sclerosis Society of America and a Biomedical Research Development Grant (RR 09026) to J.M.B.",

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AU - Hall, Edward D.

N1 - Funding Information: Methylprednisolone (sodium succinate; Solu-Medrol) was generously supplied by the UpJohn Co., Kalamazoo, Mich. The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman. This work was supported by grants to E.D.H. from the National Institute of Mental Health (MH-34111) and the Amyotrophic Lateral Sclerosis Society of America and a Biomedical Research Development Grant (RR 09026) to J.M.B.

PY - 1981/8/31

Y1 - 1981/8/31

N2 - The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.

AB - The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.

KW - (Na + K)-ATPase

KW - methylprednisolone

KW - spinal cord

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