Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

D. L. Sparks; W. R. Markesbery; J. T. Slevin

doi:10.1016/0197-4580(85)90052-1

Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

D. L. Sparks
, W. R. Markesbery
, J. T. Slevin

Producción científica: Article › revisión exhaustiva

11 Citas (Scopus)

Resumen

Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [³H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.

Idioma original	English
Páginas (desde-hasta)	213-217
Número de páginas	5
Publicación	Neurobiology of Aging
Volumen	6
N.º	3
DOI	https://doi.org/10.1016/0197-4580(85)90052-1
Estado	Published - 1985

Nota bibliográfica

Funding Information:
We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration

Financiación

We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration

Financiadores	Número del financiador
WiPL-D	N1A R01 AG02435
NINCDS
Veterans Administration
National Institute on Aging	5T32 AGO0084
National Institute of Neurological Disorders and Stroke	K07NS000732
Titanium Industry Development Association	NS00732

ASJC Scopus subject areas

General Neuroscience
Aging
Developmental Biology
Clinical Neurology
Geriatrics and Gerontology

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10.1016/0197-4580(85)90052-1

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@article{9a7017505b784a1dbbf7b293e4df8261,

title = "Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus",

abstract = "Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.",

keywords = "Aging, Hypothalamus, MAO-A, Serotonin, [H]-Spiperone",

author = "Sparks, \{D. L.\} and Markesbery, \{W. R.\} and Slevin, \{J. T.\}",

note = "Funding Information: We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration",

year = "1985",

doi = "10.1016/0197-4580(85)90052-1",

language = "English",

volume = "6",

pages = "213--217",

number = "3",

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TY - JOUR

T1 - Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

AU - Sparks, D. L.

AU - Markesbery, W. R.

AU - Slevin, J. T.

N1 - Funding Information: We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration

PY - 1985

Y1 - 1985

N2 - Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.

AB - Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.

KW - Aging

KW - Hypothalamus

KW - MAO-A

KW - Serotonin

KW - [H]-Spiperone

UR - https://www.scopus.com/pages/publications/0022353561

UR - https://www.scopus.com/pages/publications/0022353561#tab=citedBy

U2 - 10.1016/0197-4580(85)90052-1

DO - 10.1016/0197-4580(85)90052-1

M3 - Article

C2 - 2414677

AN - SCOPUS:0022353561

SN - 0197-4580

VL - 6

SP - 213

EP - 217

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 3

ER -

Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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