Resumen
Aging is the leading risk factor for idiopathic Alzheimer's disease (AD), indicating that normal aging processes promote AD and likely are present in the neurons in which AD pathogenesis originates. In AD, neurofibrillary tangles (NFTs) appear first in entorhinal cortex, implying that aging processes in entorhinal neurons promote NFT pathogenesis. Using electrophysiology and immunohistochemistry, we find pronounced aging-related Ca 2 + dysregulation in rat entorhinal neurons homologous with the human neurons in which NFTs originate. Considering that humans recapitulate many aspects of animal brain aging, these results support the hypothesis that aging-related Ca 2 + dysregulation occurs in human entorhinal neurons and promotes NFT pathogenesis.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 1371-1378 |
| Número de páginas | 8 |
| Publicación | Journal of Alzheimer's Disease |
| Volumen | 66 |
| N.º | 4 |
| DOI | |
| Estado | Published - 2018 |
Nota bibliográfica
Publisher Copyright:© 2018 - IOS Press and the authors. All rights reserved.
Financiación
This work was supported by NIH grants AG004542, AG052050, and AG037868.
| Financiadores | Número del financiador |
|---|---|
| National Institutes of Health (NIH) | AG004542, AG037868 |
| National Institute on Aging | R21AG052050 |
ODS de las Naciones Unidas
Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible
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Good health and well being
ASJC Scopus subject areas
- General Neuroscience
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Huella
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