Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats

Chun Chun Hsu; Reyno J. Tapia; Lu Yuan Lee

doi:10.1016/j.resp.2015.04.002

Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats

Chun Chun Hsu
, Reyno J. Tapia
, Lu Yuan Lee

Physiology

Producción científica: Article › revisión exhaustiva

1 Cita (Scopus)

Resumen

This study was carried out to determine whether hyperventilation of humidified warm air (HWA) induced airway extravasation in ovalbumin (Ova)-sensitized rats. Our results showed: (1) After isocapnic hyperventilation with HWA for 2min, tracheal temperature (T_tr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651% and 707%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats. (2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a pretreatment with either L-732138, a selective antagonist of neurokinin type 1 (NK-1) receptor, or formoterol, a selective agonist of β₂ adrenoceptor. This study demonstrated that an increase in airway temperature induced protein extravasation in the major airways and lung tissue of sensitized rats, and an activation of the NK-1 receptor by tachykinins released from bronchopulmonary C-fiber nerve endings was primarily responsible.

Idioma original	English
Páginas (desde-hasta)	46-49
Número de páginas	4
Publicación	Respiratory Physiology and Neurobiology
Volumen	212-214
DOI	https://doi.org/10.1016/j.resp.2015.04.002
Estado	Published - jul 1 2015

Nota bibliográfica

Publisher Copyright:
© 2015.

Financiación

This study was supported in part by US Department of Defense DMRDP/USAMRMC/TATRC Award W81XWH-10-2-0189 , NIH National Heart, Lung and Blood Institute grant HL-96914 and National Center for Advancing Translational Sciences grant UL1TR0000117 .

Financiadores	Número del financiador
U.S. Department of Defense	W81XWH-10-2-0189
National Heart, Lung, and Blood Institute (NHLBI)	R01HL096914
National Center for Advancing Translational Sciences (NCATS)	UL1TR0000117

ASJC Scopus subject areas

General Neuroscience
Physiology
Pulmonary and Respiratory Medicine

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10.1016/j.resp.2015.04.002

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title = "Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats",

abstract = "This study was carried out to determine whether hyperventilation of humidified warm air (HWA) induced airway extravasation in ovalbumin (Ova)-sensitized rats. Our results showed: (1) After isocapnic hyperventilation with HWA for 2min, tracheal temperature (Ttr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651\% and 707\%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats. (2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a pretreatment with either L-732138, a selective antagonist of neurokinin type 1 (NK-1) receptor, or formoterol, a selective agonist of β2 adrenoceptor. This study demonstrated that an increase in airway temperature induced protein extravasation in the major airways and lung tissue of sensitized rats, and an activation of the NK-1 receptor by tachykinins released from bronchopulmonary C-fiber nerve endings was primarily responsible.",

keywords = "Asthma, Bronchoconstriction, C-fiber, Tachykinins, Vagus",

author = "Hsu, \{Chun Chun\} and Tapia, \{Reyno J.\} and Lee, \{Lu Yuan\}",

note = "Publisher Copyright: {\textcopyright} 2015.",

year = "2015",

month = jul,

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doi = "10.1016/j.resp.2015.04.002",

language = "English",

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T1 - Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats

AU - Hsu, Chun Chun

AU - Tapia, Reyno J.

AU - Lee, Lu Yuan

PY - 2015/7/1

Y1 - 2015/7/1

N2 - This study was carried out to determine whether hyperventilation of humidified warm air (HWA) induced airway extravasation in ovalbumin (Ova)-sensitized rats. Our results showed: (1) After isocapnic hyperventilation with HWA for 2min, tracheal temperature (Ttr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651% and 707%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats. (2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a pretreatment with either L-732138, a selective antagonist of neurokinin type 1 (NK-1) receptor, or formoterol, a selective agonist of β2 adrenoceptor. This study demonstrated that an increase in airway temperature induced protein extravasation in the major airways and lung tissue of sensitized rats, and an activation of the NK-1 receptor by tachykinins released from bronchopulmonary C-fiber nerve endings was primarily responsible.

AB - This study was carried out to determine whether hyperventilation of humidified warm air (HWA) induced airway extravasation in ovalbumin (Ova)-sensitized rats. Our results showed: (1) After isocapnic hyperventilation with HWA for 2min, tracheal temperature (Ttr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651% and 707%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats. (2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a pretreatment with either L-732138, a selective antagonist of neurokinin type 1 (NK-1) receptor, or formoterol, a selective agonist of β2 adrenoceptor. This study demonstrated that an increase in airway temperature induced protein extravasation in the major airways and lung tissue of sensitized rats, and an activation of the NK-1 receptor by tachykinins released from bronchopulmonary C-fiber nerve endings was primarily responsible.

KW - Asthma

KW - Bronchoconstriction

KW - C-fiber

KW - Tachykinins

KW - Vagus

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UR - https://www.scopus.com/pages/publications/84928625244#tab=citedBy

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DO - 10.1016/j.resp.2015.04.002

M3 - Article

C2 - 25864799

AN - SCOPUS:84928625244

SN - 1569-9048

VL - 212-214

SP - 46

EP - 49

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

ER -

Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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