Altered Plasma Fatty Acid Abundance Is Associated with Cachexia in Treatment-Naïve Pancreatic Cancer

Kristyn Gumpper-Fedus; Phil A. Hart; Martha A. Belury; Olivia Crowe; Rachel M. Cole; Valentina Pita Grisanti; Niharika Badi; Sophia Liva; Alice Hinton; Christopher Coss; Mitchell L. Ramsey; Anne Noonan; Darwin L. Conwell; Zobeida Cruz-Monserrate

doi:10.3390/cells11050910

Altered Plasma Fatty Acid Abundance Is Associated with Cachexia in Treatment-Naïve Pancreatic Cancer

Kristyn Gumpper-Fedus
, Phil A. Hart
, Martha A. Belury
, Olivia Crowe
, Rachel M. Cole
, Valentina Pita Grisanti
, Niharika Badi
, Sophia Liva
, Alice Hinton
, Christopher Coss
, Mitchell L. Ramsey
, Anne Noonan
, Darwin L. Conwell
, Zobeida Cruz-Monserrate

Producción científica: Article › revisión exhaustiva

10 Citas (Scopus)

Resumen

Cachexia occurs in up to 80% of pancreatic ductal adenocarcinoma (PDAC) patients and is characterized by unintentional weight loss and tissue wasting. To understand the metabolic changes that occur in PDAC-associated cachexia, we compared the abundance of plasma fatty acids (FAs), measured by gas chromatography, of subjects with treatment-naïve metastatic PDAC with or without cachexia, defined as a loss of >2% weight and evidence of sarcopenia (n = 43). The abundance of saturated, monounsaturated, and polyunsaturated FAs was not different between subjects with cachexia and those without. Oleic acid was significantly higher in subjects with cachexia (p = 0.0007) and diabetes (p = 0.015). Lauric (r = 0.592, p = 0.0096) and eicosapentaenoic (r = 0.564, p = 0.015) acids were positively correlated with age in cachexia patients. Subjects with diabetes (p = 0.021) or both diabetes and cachexia (p = 0.092) had low palmitic:oleic acid ratios. Linoleic acid was lower in subjects with diabetes (p = 0.018) and correlated with hemoglobin (r = 0.519, p = 0.033) and albumin (r = 0.577, p = 0.015) in subjects with cachexia. Oleic or linoleic acid may be useful treatment targets or biomarkers of cachexia in patients with metastatic PDAC, particularly those with diabetes.

Idioma original	English
Número de artículo	910
Publicación	Cells
Volumen	11
N.º	5
DOI	https://doi.org/10.3390/cells11050910
Estado	Published - mar 1 2022

Nota bibliográfica

Publisher Copyright:
© 2022 by the authorsLicensee MDPI, Basel, Switzerland.

Financiación

Funding: Research in this publication was supported by grants from the National Center for Advancing Translational Sciences (TL1TR002735 to K.G.-F.), the National Cancer Institute (R21CA256409 to Z.C.-M., P.A.H., M.A.B., and C.C. and R21209566 to M.A.B.), the USDA National Institute of Food and Agriculture Hatch Project (M.A.B.), and by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases (U01DK108327 to D.L.C., Z.C.-M., P.A.H.). The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Advancing Translational Sciences or the National Institutes of Health. Research in this publication was supported by grants from the National Center for Advancing Translational Sciences (TL1TR002735 to K.G.-F.), the National Cancer Institute (R21CA256409 to Z.C.-M., P.A.H., M.A.B., and C.C. and R21209566 to M.A.B.), the USDA National Institute of Food and Agriculture Hatch Project (M.A.B.), and by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases (U01DK108327 to D.L.C., Z.C.-M., P.A.H.). The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Advancing Translational Sciences or the National Institutes of Health.

Financiadores	Número del financiador
USDA National Institute of Food and Agriculture
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK108327
National Childhood Cancer Registry – National Cancer Institute	R21209566, R21CA256409, R21CA209566, P30CA016058
National Center for Advancing Translational Sciences (NCATS)	TL1TR002735

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells11050910

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Gumpper-Fedus, K., Hart, P. A., Belury, M. A., Crowe, O., Cole, R. M., Grisanti, V. P., Badi, N., Liva, S., Hinton, A., Coss, C., Ramsey, M. L., Noonan, A., Conwell, D. L., & Cruz-Monserrate, Z. (2022). Altered Plasma Fatty Acid Abundance Is Associated with Cachexia in Treatment-Naïve Pancreatic Cancer. Cells, 11(5), Artículo 910. https://doi.org/10.3390/cells11050910

@article{7d10c5a5bc6246868682dd1922606ce3,

title = "Altered Plasma Fatty Acid Abundance Is Associated with Cachexia in Treatment-Na{\"i}ve Pancreatic Cancer",

abstract = "Cachexia occurs in up to 80\% of pancreatic ductal adenocarcinoma (PDAC) patients and is characterized by unintentional weight loss and tissue wasting. To understand the metabolic changes that occur in PDAC-associated cachexia, we compared the abundance of plasma fatty acids (FAs), measured by gas chromatography, of subjects with treatment-na{\"i}ve metastatic PDAC with or without cachexia, defined as a loss of >2\% weight and evidence of sarcopenia (n = 43). The abundance of saturated, monounsaturated, and polyunsaturated FAs was not different between subjects with cachexia and those without. Oleic acid was significantly higher in subjects with cachexia (p = 0.0007) and diabetes (p = 0.015). Lauric (r = 0.592, p = 0.0096) and eicosapentaenoic (r = 0.564, p = 0.015) acids were positively correlated with age in cachexia patients. Subjects with diabetes (p = 0.021) or both diabetes and cachexia (p = 0.092) had low palmitic:oleic acid ratios. Linoleic acid was lower in subjects with diabetes (p = 0.018) and correlated with hemoglobin (r = 0.519, p = 0.033) and albumin (r = 0.577, p = 0.015) in subjects with cachexia. Oleic or linoleic acid may be useful treatment targets or biomarkers of cachexia in patients with metastatic PDAC, particularly those with diabetes.",

keywords = "Albumin, Diabetes, Fatty acids, Hemoglobin, Linoleic acid, Oleic acid, Pancreatic cancer, Sarcopenia",

author = "Kristyn Gumpper-Fedus and Hart, \{Phil A.\} and Belury, \{Martha A.\} and Olivia Crowe and Cole, \{Rachel M.\} and Grisanti, \{Valentina Pita\} and Niharika Badi and Sophia Liva and Alice Hinton and Christopher Coss and Ramsey, \{Mitchell L.\} and Anne Noonan and Conwell, \{Darwin L.\} and Zobeida Cruz-Monserrate",

note = "Publisher Copyright: {\textcopyright} 2022 by the authorsLicensee MDPI, Basel, Switzerland.",

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AU - Gumpper-Fedus, Kristyn

AU - Hart, Phil A.

AU - Belury, Martha A.

AU - Crowe, Olivia

AU - Cole, Rachel M.

AU - Grisanti, Valentina Pita

AU - Badi, Niharika

AU - Liva, Sophia

AU - Hinton, Alice

AU - Coss, Christopher

AU - Ramsey, Mitchell L.

AU - Noonan, Anne

AU - Conwell, Darwin L.

AU - Cruz-Monserrate, Zobeida

PY - 2022/3/1

Y1 - 2022/3/1

N2 - Cachexia occurs in up to 80% of pancreatic ductal adenocarcinoma (PDAC) patients and is characterized by unintentional weight loss and tissue wasting. To understand the metabolic changes that occur in PDAC-associated cachexia, we compared the abundance of plasma fatty acids (FAs), measured by gas chromatography, of subjects with treatment-naïve metastatic PDAC with or without cachexia, defined as a loss of >2% weight and evidence of sarcopenia (n = 43). The abundance of saturated, monounsaturated, and polyunsaturated FAs was not different between subjects with cachexia and those without. Oleic acid was significantly higher in subjects with cachexia (p = 0.0007) and diabetes (p = 0.015). Lauric (r = 0.592, p = 0.0096) and eicosapentaenoic (r = 0.564, p = 0.015) acids were positively correlated with age in cachexia patients. Subjects with diabetes (p = 0.021) or both diabetes and cachexia (p = 0.092) had low palmitic:oleic acid ratios. Linoleic acid was lower in subjects with diabetes (p = 0.018) and correlated with hemoglobin (r = 0.519, p = 0.033) and albumin (r = 0.577, p = 0.015) in subjects with cachexia. Oleic or linoleic acid may be useful treatment targets or biomarkers of cachexia in patients with metastatic PDAC, particularly those with diabetes.

AB - Cachexia occurs in up to 80% of pancreatic ductal adenocarcinoma (PDAC) patients and is characterized by unintentional weight loss and tissue wasting. To understand the metabolic changes that occur in PDAC-associated cachexia, we compared the abundance of plasma fatty acids (FAs), measured by gas chromatography, of subjects with treatment-naïve metastatic PDAC with or without cachexia, defined as a loss of >2% weight and evidence of sarcopenia (n = 43). The abundance of saturated, monounsaturated, and polyunsaturated FAs was not different between subjects with cachexia and those without. Oleic acid was significantly higher in subjects with cachexia (p = 0.0007) and diabetes (p = 0.015). Lauric (r = 0.592, p = 0.0096) and eicosapentaenoic (r = 0.564, p = 0.015) acids were positively correlated with age in cachexia patients. Subjects with diabetes (p = 0.021) or both diabetes and cachexia (p = 0.092) had low palmitic:oleic acid ratios. Linoleic acid was lower in subjects with diabetes (p = 0.018) and correlated with hemoglobin (r = 0.519, p = 0.033) and albumin (r = 0.577, p = 0.015) in subjects with cachexia. Oleic or linoleic acid may be useful treatment targets or biomarkers of cachexia in patients with metastatic PDAC, particularly those with diabetes.

KW - Albumin

KW - Diabetes

KW - Fatty acids

KW - Hemoglobin

KW - Linoleic acid

KW - Oleic acid

KW - Pancreatic cancer

KW - Sarcopenia

UR - https://www.scopus.com/pages/publications/85125995386

UR - https://www.scopus.com/pages/publications/85125995386#tab=citedBy

U2 - 10.3390/cells11050910

DO - 10.3390/cells11050910

M3 - Article

C2 - 35269531

AN - SCOPUS:85125995386

VL - 11

JO - Cells

JF - Cells

IS - 5

M1 - 910

ER -

Altered Plasma Fatty Acid Abundance Is Associated with Cachexia in Treatment-Naïve Pancreatic Cancer

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

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