Ameloblastic fibroma: A fine-needle aspiration case report

Fine-needle aspiration biopsy of an ameloblastic fibroma, an unusual odontogenic tumor related to ameloblastoma, was performed on a 38-yr-old man with a slowly enlarging left facial mass. Aspiration of the tumor yielded a cellular sample composed of a mixture of mesenchymal and epithelial cells, arranged, respectively, in thick mats and complex solid structures outlined by columnar cells with central regions reminiscent of stellate reticulum. A diagnosis of odontogenic tumor was conferred, and the lesion was surgically biopsied and then resected. The key cytologic feature distinguishing this lesion from other odontogenic tumors was fragments of hypercellular stroma. The differential diagnosis includes ameloblastoma, ameloblastic fibrosarcoma, other odontogenic tumors, intraosseous adenoid cystic carcinoma, trabecular adenoma, and basal-cell carcinoma.