Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis

Young Ok Son; Poyil Pratheeshkumar; Ram Vinod Roy; John Andrew Hitron; Lei Wang; Sasidharan Padmaja Divya; Mei Xu; Jia Luo; Gang Chen; Zhuo Zhang; Xianglin Shi

doi:10.1074/jbc.M115.675371

Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis

Young Ok Son
, Poyil Pratheeshkumar
, Ram Vinod Roy
, John Andrew Hitron
, Lei Wang
, Sasidharan Padmaja Divya
, Mei Xu
, Jia Luo
, Gang Chen
, Zhuo Zhang
, Xianglin Shi

Producción científica: Article › revisión exhaustiva

31 Citas (Scopus)

Resumen

Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.

Idioma original	English
Páginas (desde-hasta)	27090-27100
Número de páginas	11
Publicación	Journal of Biological Chemistry
Volumen	290
N.º	45
DOI	https://doi.org/10.1074/jbc.M115.675371
Estado	Published - nov 6 2015

Nota bibliográfica

Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Financiación

Financiadores	Número del financiador
National Institutes of Health (NIH)	R01 ES021771, R01 ES025515
National Institutes of Health/National Institute of Environmental Health Sciences	T32ES007266

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis",

abstract = "Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.",

author = "Son, \{Young Ok\} and Poyil Pratheeshkumar and Roy, \{Ram Vinod\} and Hitron, \{John Andrew\} and Lei Wang and Divya, \{Sasidharan Padmaja\} and Mei Xu and Jia Luo and Gang Chen and Zhuo Zhang and Xianglin Shi",

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AU - Son, Young Ok

AU - Pratheeshkumar, Poyil

AU - Roy, Ram Vinod

AU - Hitron, John Andrew

AU - Wang, Lei

AU - Divya, Sasidharan Padmaja

AU - Xu, Mei

AU - Luo, Jia

AU - Chen, Gang

AU - Zhang, Zhuo

AU - Shi, Xianglin

PY - 2015/11/6

Y1 - 2015/11/6

N2 - Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.

AB - Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.

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U2 - 10.1074/jbc.M115.675371

DO - 10.1074/jbc.M115.675371

M3 - Article

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AN - SCOPUS:84946781660

SN - 0021-9258

VL - 290

SP - 27090

EP - 27100

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 45

ER -

Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis

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