Antisense oligonucleotides targeting angiotensinogen: Insights from animal studies

Chia Hua Wu; Ya Wang; Murong Ma; Adam E. Mullick; Rosanne M. Crooke; Mark J. Graham; Alan Daugherty; Hong S. Lu

doi:10.1042/BSR20180201

Antisense oligonucleotides targeting angiotensinogen: Insights from animal studies

Chia Hua Wu
, Ya Wang
, Murong Ma
, Adam E. Mullick
, Rosanne M. Crooke
, Mark J. Graham
, Alan Daugherty
, Hong S. Lu

Producción científica: Review article › revisión exhaustiva

20 Citas (Scopus)

Resumen

Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and pathophysiological roles mediated by AGT.

Idioma original	English
Número de artículo	BSR20180201
Publicación	Bioscience Reports
Volumen	39
N.º	1
DOI	https://doi.org/10.1042/BSR20180201
Estado	Published - ene 11 2019

Nota bibliográfica

Publisher Copyright:
© 2019 The Author(s).

Financiación

The authors’ research work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health [grant numbers R01HL139748, R01HL133723] and the National Natural Science Foundation of China [grant numbers 81320108003, 31371498 (to Y.W.)]; Employees of Ionis Pharmaceuticals, Inc. [to A.E.M. and R.M.C.]; M.J.G. was an employee of Ionis Pharmaceuticals, Inc. The content in this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Financiadores	Número del financiador
Employees of Ionis Pharmaceuticals, Inc.
National Institutes of Health (NIH)	R01HL139748
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)	R01HL133723
National Heart, Lung, and Blood Institute (NHLBI)
ISIS Pharmaceuticals
National Natural Science Foundation of China (NSFC)	31371498, 81320108003
National Natural Science Foundation of China (NSFC)

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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AU - Daugherty, Alan

AU - Lu, Hong S.

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Antisense oligonucleotides targeting angiotensinogen: Insights from animal studies

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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