Assessing interactions for fixed-dose drug combinations in tumor xenograft studies

Jianrong Wu; Lorraine Tracey; Andrew M. Davidoff

doi:10.1080/10543406.2011.556285

Assessing interactions for fixed-dose drug combinations in tumor xenograft studies

Jianrong Wu
, Lorraine Tracey
, Andrew M. Davidoff

Internal Medicine

Producción científica: Article › revisión exhaustiva

12 Citas (Scopus)

Resumen

Statistical methods for assessing the joint action of compounds administered in combination have been established for many years. However, there is little literature available on assessing the joint action of fixed-dose drug combinations in tumor xenograft experiments. Here an interaction index for fixed-dose two-drug combinations is proposed. Furthermore, a regression analysis is also discussed. Actual tumor xenograft data were analyzed to illustrate the proposed methods.

Idioma original	English
Páginas (desde-hasta)	535-543
Número de páginas	9
Publicación	Journal of Biopharmaceutical Statistics
Volumen	22
N.º	3
DOI	https://doi.org/10.1080/10543406.2011.556285
Estado	Published - may 1 2012

Nota bibliográfica

Funding Information:
The authors are thankful to a anonymous referee whose comments improved this article. This work was supported in part by National Cancer Institute (NCI) support grant CA21765, CA23099, by the ASSISI Foundation of Memphis, and by the American Lebanese Syrian Associated Charities (ALSAC).

Financiación

The authors are thankful to a anonymous referee whose comments improved this article. This work was supported in part by National Cancer Institute (NCI) support grant CA21765, CA23099, by the ASSISI Foundation of Memphis, and by the American Lebanese Syrian Associated Charities (ALSAC).

Financiadores	Número del financiador
National Childhood Cancer Registry – National Cancer Institute	P30CA021765, CA23099
Assisi Foundation of Memphis
American Lebanese Syrian Associated Charities

ASJC Scopus subject areas

Statistics and Probability
Pharmacology
Pharmacology (medical)

Acceder al documento

10.1080/10543406.2011.556285

Otros archivos y enlaces

Citar esto

@article{d23099850dc14ff5a53f18c65de00686,

title = "Assessing interactions for fixed-dose drug combinations in tumor xenograft studies",

abstract = "Statistical methods for assessing the joint action of compounds administered in combination have been established for many years. However, there is little literature available on assessing the joint action of fixed-dose drug combinations in tumor xenograft experiments. Here an interaction index for fixed-dose two-drug combinations is proposed. Furthermore, a regression analysis is also discussed. Actual tumor xenograft data were analyzed to illustrate the proposed methods.",

keywords = "Bootstrap, Confidence interval, Drug combination, Regression, Xenograft model",

author = "Jianrong Wu and Lorraine Tracey and Davidoff, \{Andrew M.\}",

note = "Funding Information: The authors are thankful to a anonymous referee whose comments improved this article. This work was supported in part by National Cancer Institute (NCI) support grant CA21765, CA23099, by the ASSISI Foundation of Memphis, and by the American Lebanese Syrian Associated Charities (ALSAC).",

year = "2012",

month = may,

day = "1",

doi = "10.1080/10543406.2011.556285",

language = "English",

volume = "22",

pages = "535--543",

number = "3",

}

TY - JOUR

T1 - Assessing interactions for fixed-dose drug combinations in tumor xenograft studies

AU - Wu, Jianrong

AU - Tracey, Lorraine

AU - Davidoff, Andrew M.

N1 - Funding Information: The authors are thankful to a anonymous referee whose comments improved this article. This work was supported in part by National Cancer Institute (NCI) support grant CA21765, CA23099, by the ASSISI Foundation of Memphis, and by the American Lebanese Syrian Associated Charities (ALSAC).

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Statistical methods for assessing the joint action of compounds administered in combination have been established for many years. However, there is little literature available on assessing the joint action of fixed-dose drug combinations in tumor xenograft experiments. Here an interaction index for fixed-dose two-drug combinations is proposed. Furthermore, a regression analysis is also discussed. Actual tumor xenograft data were analyzed to illustrate the proposed methods.

AB - Statistical methods for assessing the joint action of compounds administered in combination have been established for many years. However, there is little literature available on assessing the joint action of fixed-dose drug combinations in tumor xenograft experiments. Here an interaction index for fixed-dose two-drug combinations is proposed. Furthermore, a regression analysis is also discussed. Actual tumor xenograft data were analyzed to illustrate the proposed methods.

KW - Bootstrap

KW - Confidence interval

KW - Drug combination

KW - Regression

KW - Xenograft model

UR - https://www.scopus.com/pages/publications/84859208924

UR - https://www.scopus.com/pages/publications/84859208924#tab=citedBy

U2 - 10.1080/10543406.2011.556285

DO - 10.1080/10543406.2011.556285

M3 - Article

C2 - 22416839

AN - SCOPUS:84859208924

SN - 1054-3406

VL - 22

SP - 535

EP - 543

JO - Journal of Biopharmaceutical Statistics

JF - Journal of Biopharmaceutical Statistics

IS - 3

ER -

Assessing interactions for fixed-dose drug combinations in tumor xenograft studies

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto