Resumen
BACKGROUND: Cardiovascular disease (CVD) and cancer frequently co-occur due to shared risk factors such as obesity, which is linked to CVD and 14 cancer types. This study explores whether CVD pathophysiologies, combined with obesity, increase cancer risk, impacting clinical management. METHODS AND RESULTS: Data from the ARIC (Atherosclerosis Risk in Communities) study, spanning 28 years, were analyzed. The cohort included 5127 participants with incident CVD (myocardial infarction, stroke, heart failure, coronary heart disease), of whom 1511 developed a first primary cancer. Follow-up began at CVD diagnosis after Visit 1. Obesity was assessed using body mass index, waist circumference, and waist-to-hip ratio. Incidence rate differences between obesity groups were adjusted for age, sex, and center, whereas the obesity–cancer association was estimated using Fine-Gray regression adjusted for shared risk factors including smoking. Cancer incidence in obese individuals with CVD (body mass index: rate differ-ences=226.6/100 000 person-years) was higher than in those with normal weight. Although obesity was not linked to overall cancer after adjusting for shared risk factors, it was nominally associated with obesity-related cancers. Specifically, women with CVD and obesity had increased obesity-related cancer risk (body mass index: hazard ratio, 1.67 [95% CI, 1.17–2.31]). No significant associations were found in men, even after excluding prostate cancer. CONCLUSIONS: This study suggests that obesity is linked to higher obesity-related cancer risk in women with incident CVD, independent of shared risk factors. Further research is needed to eliminate residual confounding, understand sex differences, and explore how CVD pathophysiologies and obesity together influence cancer risk.
| Idioma original | English |
|---|---|
| Número de artículo | e034438 |
| Publicación | Journal of the American Heart Association |
| Volumen | 13 |
| N.º | 17 |
| DOI | |
| Estado | Published - sept 3 2024 |
Nota bibliográfica
Publisher Copyright:© 2024 The Author(s).
Financiación
The authors thank the staff and participants of the ARIC study for their important contributions. Cancer data were provided by the Maryland Cancer Registry, Center for Cancer Prevention and Control, Maryland Department of Health, with funding from the State of Maryland and the Maryland Cigarette Restitution Fund. The collection and availability of cancer registry data are also supported by the Cooperative Agreement NU58DP007114, funded by the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention or the Department of Health and Human Services. This work is supported by American Heart Association–Strategically Focused Research Network Grant in Disparities in Cardio-Oncology (number 847740, number 863620) and Department of Defense Prostate Cancer Research Program’s Physician Research Award (number HT94252310158) The ARIC study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services (under contract numbers 75N92022D00001, 75N92022D00002, 75N92022D00003, 75N92022D00004, and 75N92022D00005). Studies on cancer in the ARIC study are also supported by the National Cancer Institute (U01 CA164975). The content of this work is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
| Financiadores | Número del financiador |
|---|---|
| Centers for Disease Control and Prevention | |
| State of Maryland Office of the Chief Medical Examiner | |
| Maryland Department of Health | |
| National Institutes of Health (NIH) | |
| Prostate Cancer Research Program’s Physician Research Award | |
| National Heart, Lung, and Blood Institute (NHLBI) | |
| Maryland Cancer Registry | |
| American the American Heart Association | 847740, 863620 |
| National Childhood Cancer Registry – National Cancer Institute | U01 CA164975 |
| U.S. Department of Health and Human Services | 75N92022D00003, 75N92022D00004, 75N92022D00001, 75N92022D00002, 75N92022D00005 |
| Maryland Cigarette Restitution Fund | NU58DP007114 |
| U.S. Department of Defense | HT94252310158 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
ODS de las Naciones Unidas
Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible
