Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health

doi:10.1016/j.cgh.2022.09.026

Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health

,

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Resumen

Background and Aims: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities. Methods: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants completed the PROMIS-Global Health, which captures global physical and mental health, and the PROMIS-29 profile, which captures 7 symptom domains. Self-reported pain was categorized by severity (none, mild-moderate, severe) and temporal nature (none, intermittent, constant). Demographic and clinical data were obtained from the PROCEED database. Results: Pain was significantly associated with impairments in physical and mental health. Compared with participants with no pain, CP participants with severe pain (but not mild-moderate pain) had more decrements in each PROMIS domain in multivariable models (effect sizes, 2.54–7.03) and had a higher prevalence of clinically significant depression, anxiety, sleep disturbance, and physical disability (odds ratios, 2.11–4.74). Similar results were noted for constant pain (but not intermittent pain) for PROMIS domains (effect sizes, 4.08–10.37) and clinically significant depression, anxiety, sleep disturbance and physical disability (odds ratios, 2.80–5.38). Conclusions: Severe and constant pain are major drivers for poor psychological and physical health in CP. Systematic evaluation and management of psychiatric comorbidities and sleep disturbance should be incorporated into routine management of patients with CP. (ClinicalTrials.gov, Number: NCT03099850).

Idioma original	English
Páginas (desde-hasta)	1781-1791.e4
Publicación	Clinical Gastroenterology and Hepatology
Volumen	21
N.º	7
DOI	https://doi.org/10.1016/j.cgh.2022.09.026
Estado	Published - jul 2023

Nota bibliográfica

Publisher Copyright:
© 2023 AGA Institute

Financiación

Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers U01DK108288 (to Mark D. Topazian, Santhi Swaroop Vege), U01DK108300 (to Walter G. Park), U01DK108306 (to Dhiraj Yadav), U01DK108314 (to Stephen J. Pandol), UO1DK108320 (to Christopher E. Forsmark), U01DK108323 (to Evan L. Fogel), U01DK108326 (to William E. Fisher), U01DK108327 (to Phil A. Hart, Darwin L. Conwell), UO1DK108322 (to Stephen K. Van Den Eeden), and U01DK108328 (to Liang Li, Minxing Chen, Yunlong Yang). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers U01DK108288 (to Mark D. Topazian, Santhi Swaroop Vege), U01DK108300 (to Walter G. Park), U01DK108306 (to Dhiraj Yadav), U01DK108314 (to Stephen J. Pandol), UO1DK108320 (to Christopher E. Forsmark), U01DK108323 (to Evan L. Fogel), U01DK108326 (to William E. Fisher), U01DK108327 (to Phil A. Hart, Darwin L. Conwell), UO1DK108322 (to Stephen K. Van Den Eeden), and U01DK108328 (to Liang Li, Minxing Chen, Yunlong Yang). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK108306, U01DK108328, U01DK108327, U01DK108323, U01DK108326, U01DK108314, UO1DK108320, UO1DK108322, U01DK108300, U01DK108288
National Institute of Diabetes and Digestive and Kidney Diseases

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Hepatology
Gastroenterology

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@article{303bd4fd8ebd452aba38ce303b6a47e6,

title = "Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health",

abstract = "Background and Aims: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities. Methods: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants completed the PROMIS-Global Health, which captures global physical and mental health, and the PROMIS-29 profile, which captures 7 symptom domains. Self-reported pain was categorized by severity (none, mild-moderate, severe) and temporal nature (none, intermittent, constant). Demographic and clinical data were obtained from the PROCEED database. Results: Pain was significantly associated with impairments in physical and mental health. Compared with participants with no pain, CP participants with severe pain (but not mild-moderate pain) had more decrements in each PROMIS domain in multivariable models (effect sizes, 2.54–7.03) and had a higher prevalence of clinically significant depression, anxiety, sleep disturbance, and physical disability (odds ratios, 2.11–4.74). Similar results were noted for constant pain (but not intermittent pain) for PROMIS domains (effect sizes, 4.08–10.37) and clinically significant depression, anxiety, sleep disturbance and physical disability (odds ratios, 2.80–5.38). Conclusions: Severe and constant pain are major drivers for poor psychological and physical health in CP. Systematic evaluation and management of psychiatric comorbidities and sleep disturbance should be incorporated into routine management of patients with CP. (ClinicalTrials.gov, Number: NCT03099850).",

keywords = "Anxiety, Depression, PROMIS, Pancreas, Pancreatitis, Sleep disturbance",

author = "Dhiraj Yadav and Askew, \{Robert L.\} and Tonya Palermo and Liang Li and Andersen, \{Dana K.\} and Minxing Chen and Fisher, \{William E.\} and Fogel, \{Evan L.\} and Forsmark, \{Christopher E.\} and Hart, \{Phil A.\} and Othman, \{Mohamed O.\} and Pandol, \{Stephen J.\} and Park, \{Walter G.\} and Topazian, \{Mark D.\} and \{Van Den Eeden\}, \{Stephen K.\} and Vege, \{Santhi Swaroop\} and Yunlong Yang and Jose Serrano and Conwell, \{Darwin L.\}",

note = "Publisher Copyright: {\textcopyright} 2023 AGA Institute",

year = "2023",

month = jul,

doi = "10.1016/j.cgh.2022.09.026",

language = "English",

volume = "21",

pages = "1781--1791.e4",

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T1 - Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health

AU - Yadav, Dhiraj

AU - Askew, Robert L.

AU - Palermo, Tonya

AU - Li, Liang

AU - Andersen, Dana K.

AU - Chen, Minxing

AU - Fisher, William E.

AU - Fogel, Evan L.

AU - Forsmark, Christopher E.

AU - Hart, Phil A.

AU - Othman, Mohamed O.

AU - Pandol, Stephen J.

AU - Park, Walter G.

AU - Topazian, Mark D.

AU - Van Den Eeden, Stephen K.

AU - Vege, Santhi Swaroop

AU - Yang, Yunlong

AU - Serrano, Jose

AU - Conwell, Darwin L.

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AB - Background and Aims: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities. Methods: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants completed the PROMIS-Global Health, which captures global physical and mental health, and the PROMIS-29 profile, which captures 7 symptom domains. Self-reported pain was categorized by severity (none, mild-moderate, severe) and temporal nature (none, intermittent, constant). Demographic and clinical data were obtained from the PROCEED database. Results: Pain was significantly associated with impairments in physical and mental health. Compared with participants with no pain, CP participants with severe pain (but not mild-moderate pain) had more decrements in each PROMIS domain in multivariable models (effect sizes, 2.54–7.03) and had a higher prevalence of clinically significant depression, anxiety, sleep disturbance, and physical disability (odds ratios, 2.11–4.74). Similar results were noted for constant pain (but not intermittent pain) for PROMIS domains (effect sizes, 4.08–10.37) and clinically significant depression, anxiety, sleep disturbance and physical disability (odds ratios, 2.80–5.38). Conclusions: Severe and constant pain are major drivers for poor psychological and physical health in CP. Systematic evaluation and management of psychiatric comorbidities and sleep disturbance should be incorporated into routine management of patients with CP. (ClinicalTrials.gov, Number: NCT03099850).

KW - Anxiety

KW - Depression

KW - PROMIS

KW - Pancreas

KW - Pancreatitis

KW - Sleep disturbance

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Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health

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Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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