Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

doi:10.1016/j.cgh.2021.11.011

Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Producción científica: Short survey › revisión exhaustiva

15 Citas (Scopus)

Resumen

Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation. 1.

Idioma original	English
Páginas (desde-hasta)	226-228.e1
Publicación	Clinical Gastroenterology and Hepatology
Volumen	21
N.º	1
DOI	https://doi.org/10.1016/j.cgh.2021.11.011
Estado	Published - ene 2023

Nota bibliográfica

Funding Information:
Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funding Information:
Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Copyright © 2023. Published by Elsevier Inc.

Financiación

Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK108306, DK061451, UO1 DK126300, UO1 DK127367, DK077906, UO1 DK127377
National Institute of Diabetes and Digestive and Kidney Diseases

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/j.cgh.2021.11.011

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title = "Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study",

abstract = "Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25\%-75\% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from {"}bystander{"} injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation. 1. ",

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author = "Dhiraj Yadav and Whitcomb, \{David C.\} and Gong Tang and Adam Slivka and Melena Bellin and Samer AlKaade and Amann, \{Stephen T.\} and Anderson, \{Michelle A.\} and Peter Banks and Darwin Conwell and Brand, \{Randall E.\} and Cote, \{Gregory A.\} and Joseph Romagnuolo and Forsmark, \{Christopher E.\} and Timothy Gardner and Andres Gelrud and Nalini Guda and Michele Lewis and Thiruvengadam Muniraj and Sandhu, \{Bimaljit S.\} and Stuart Sherman and Vikesh Singh and Wilcox, \{C. Mel\}",

note = "Funding Information: Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Copyright {\textcopyright} 2023. Published by Elsevier Inc.",

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T2 - A Pilot Study

AU - Yadav, Dhiraj

AU - Whitcomb, David C.

AU - Tang, Gong

AU - Slivka, Adam

AU - Bellin, Melena

AU - AlKaade, Samer

AU - Amann, Stephen T.

AU - Anderson, Michelle A.

AU - Banks, Peter

AU - Conwell, Darwin

AU - Brand, Randall E.

AU - Cote, Gregory A.

AU - Romagnuolo, Joseph

AU - Forsmark, Christopher E.

AU - Gardner, Timothy

AU - Gelrud, Andres

AU - Guda, Nalini

AU - Lewis, Michele

AU - Muniraj, Thiruvengadam

AU - Sandhu, Bimaljit S.

AU - Sherman, Stuart

AU - Singh, Vikesh

AU - Wilcox, C. Mel

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PY - 2023/1

Y1 - 2023/1

N2 - Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation. 1.

AB - Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation. 1.

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KW - Pilot Projects

KW - Humans

KW - Adult

KW - Pancreatitis, Chronic/complications

KW - Diabetes Mellitus

KW - Insulin

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DO - 10.1016/j.cgh.2021.11.011

M3 - Short survey

C2 - 34793964

AN - SCOPUS:85121720316

SN - 1542-3565

VL - 21

SP - 226-228.e1

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 1

ER -

Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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