Autoregulation of Cardiac L-type calcium channels

Jonathan Satin; Elizabeth A. Schroder

doi:10.1016/j.tcm.2010.02.009

Autoregulation of Cardiac L-type calcium channels

Producción científica: Review article › revisión exhaustiva

10 Citas (Scopus)

Resumen

l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.

Idioma original	English
Páginas (desde-hasta)	268-271
Número de páginas	4
Publicación	Trends in Cardiovascular Medicine
Volumen	19
N.º	8
DOI	https://doi.org/10.1016/j.tcm.2010.02.009
Estado	Published - nov 2009

Nota bibliográfica

Funding Information:
Supported by a grant from the National Institutes of Health HL-07491 (JS). The authors thank Dr Brian P Delisle for helpful comments.

Financiación

Supported by a grant from the National Institutes of Health HL-07491 (JS). The authors thank Dr Brian P Delisle for helpful comments.

Financiadores	Número del financiador
National Institutes of Health (NIH)	HL-07491
National Heart, Lung, and Blood Institute (NHLBI)	R01HL074091

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.tcm.2010.02.009

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title = "Autoregulation of Cardiac L-type calcium channels",

abstract = "l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.",

author = "Jonathan Satin and Schroder, \{Elizabeth A.\}",

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AU - Schroder, Elizabeth A.

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PY - 2009/11

Y1 - 2009/11

N2 - l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.

AB - l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.

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DO - 10.1016/j.tcm.2010.02.009

M3 - Review article

C2 - 20447569

AN - SCOPUS:77952501201

SN - 1050-1738

VL - 19

SP - 268

EP - 271

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 8

ER -

Autoregulation of Cardiac L-type calcium channels

Resumen

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