Biosynthetic Origin of the Oxygen Atoms of Tetracenomycin C

Györgyi Udvarnoki; Christina Wagner; Reinhard Machinek; Jürgen Rohr

doi:10.1002/anie.199505651

Biosynthetic Origin of the Oxygen Atoms of Tetracenomycin C

Györgyi Udvarnoki
, Christina Wagner
, Reinhard Machinek
, Jürgen Rohr

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

14 Citas (Scopus)

Resumen

Water and not acetate is the source of the oxygen atom 4a‐OH in the biosynthesis of tetracenomycin C. Based on this unusual finding, an intermediate epoxide is postulated, which has to be “cis opened” to attain the required stereochemistry at C‐4a and C‐12a (see reaction sequence below). (Figure Presented.)

Idioma original	English
Páginas (desde-hasta)	565-567
Número de páginas	3
Publicación	Angewandte Chemie International Edition in English
Volumen	34
N.º	5
DOI	https://doi.org/10.1002/anie.199505651
Estado	Published - mar 20 1995

ASJC Scopus subject areas

Catalysis
General Chemistry

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title = "Biosynthetic Origin of the Oxygen Atoms of Tetracenomycin C",

abstract = "Water and not acetate is the source of the oxygen atom 4a‐OH in the biosynthesis of tetracenomycin C. Based on this unusual finding, an intermediate epoxide is postulated, which has to be “cis opened” to attain the required stereochemistry at C‐4a and C‐12a (see reaction sequence below). (Figure Presented.)",

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AU - Udvarnoki, Györgyi

AU - Wagner, Christina

AU - Machinek, Reinhard

AU - Rohr, Jürgen

PY - 1995/3/20

Y1 - 1995/3/20

N2 - Water and not acetate is the source of the oxygen atom 4a‐OH in the biosynthesis of tetracenomycin C. Based on this unusual finding, an intermediate epoxide is postulated, which has to be “cis opened” to attain the required stereochemistry at C‐4a and C‐12a (see reaction sequence below). (Figure Presented.)

AB - Water and not acetate is the source of the oxygen atom 4a‐OH in the biosynthesis of tetracenomycin C. Based on this unusual finding, an intermediate epoxide is postulated, which has to be “cis opened” to attain the required stereochemistry at C‐4a and C‐12a (see reaction sequence below). (Figure Presented.)

KW - biosynthesis

KW - natural products

KW - tetracenomycin C

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UR - https://www.scopus.com/pages/publications/0029163689#tab=citedBy

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DO - 10.1002/anie.199505651

M3 - Article

AN - SCOPUS:0029163689

SN - 0570-0833

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JO - Angewandte Chemie International Edition in English

JF - Angewandte Chemie International Edition in English

IS - 5

ER -

Biosynthetic Origin of the Oxygen Atoms of Tetracenomycin C

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