Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Vitaliy Sviripa; Michael D. Conroy; Wen Zhang; Alice Liu; David S. Watt

doi:10.3906/kim-1302-78

Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Vitaliy Sviripa
, Michael D. Conroy
, Wen Zhang
, Alice Liu
, David S. Watt

Molecular and Cellular Biochemistry

Producción científica: Article › revisión exhaustiva

Resumen

Biotinylated analogs of drug candidates provide useful tools for studying the drug-target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.

Idioma original	English
Páginas (desde-hasta)	473-479
Número de páginas	7
Publicación	Turkish Journal of Chemistry
Volumen	37
N.º	4
DOI	https://doi.org/10.3906/kim-1302-78
Estado	Published - 2013

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

General Chemistry

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10.3906/kim-1302-78

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title = "Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)",

abstract = "Biotinylated analogs of drug candidates provide useful tools for studying the drug-target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.",

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T1 - Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

AU - Sviripa, Vitaliy

AU - Conroy, Michael D.

AU - Zhang, Wen

AU - Liu, Alice

AU - Watt, David S.

PY - 2013

Y1 - 2013

N2 - Biotinylated analogs of drug candidates provide useful tools for studying the drug-target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.

AB - Biotinylated analogs of drug candidates provide useful tools for studying the drug-target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.

KW - Adenosine monophosphate-activated kinase

KW - Biotinylated N,N'-diarylureas

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UR - https://www.scopus.com/pages/publications/84880833084#tab=citedBy

U2 - 10.3906/kim-1302-78

DO - 10.3906/kim-1302-78

M3 - Article

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JO - Turkish Journal of Chemistry

JF - Turkish Journal of Chemistry

IS - 4

ER -

Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Resumen

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